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Titolo:
Antithyroid-drug-induced agranulocytosis complicated by life-threatening infections
Autore:
Sheng, WH; Hung, CC; Chen, YC; Fang, CT; Hsieh, SM; Chang, SC; Hsieh, WC;
Indirizzi:
Natl Taiwan Univ Hosp, Dept Internal Med, Infect Dis Sect, Taipei 100, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan 100 ect Dis Sect, Taipei 100, Taiwan
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 8, volume: 92, anno: 1999,
pagine: 455 - 461
SICI:
1460-2725(199908)92:8<455:AACBLI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; CARBIMAZOLE-INDUCED AGRANULOCYTOSIS; METHIMAZOLE-INDUCED AGRANULOCYTOSIS; BUCCAL EPITHELIAL-CELLS; FACTOR G-CSF; PSEUDOMONAS-AERUGINOSA; PROPYLTHIOURACIL; ADHERENCE; THERAPY; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, SC Natl Taiwan Univ Hosp, Dept Internal Med, Infect Dis Sect, 7 Chung Shan S Rd, Taipei 100, Taiwan Natl Taiwan Univ Hosp 7 Chung Shan S Rd Taipei Taiwan 100 aiwan
Citazione:
W.H. Sheng et al., "Antithyroid-drug-induced agranulocytosis complicated by life-threatening infections", QJM-MON J A, 92(8), 1999, pp. 455-461

Abstract

Agranulocytosis is a rare complication of antithyroid drugs, and the aetiologies of community-acquired, rife-threatening infections in patients taking these drugs have not previously been systematically described. Of 5653 hyperthyroid patients treated with antithyroid drugs at National Taiwan University Hospital between January 1987 and December 1997, 13 (0.23%) developedagranulocytosis with life-threatening infections. The most common presentations were fever (92%) and sore throat (85%). Initial clinical diagnoses were acute pharyngitis (46%), acute tonsillitis (38%), pneumonia (15%) and urinary tract infection (8%). Positive blood cultures from six patients yielded Pseudomonas aeruginosa (3), Escherichia coli (1), Staphylococcus aureus (1), Capnocytophaga species (1). Two patients died of uncontrolled infection, thyroid storm and multiple organ failure. Cases of antithyroid-drug-induced agranulocytosis in the English language literature are reviewed; Gram-negative bacilli, including Klebsiella pneumoniae (4 patients) and P. aeruginosa (3), were the most common pathogens in clinical isolates. Our observation and review suggest that broad-spectrum antibiotics with antipseudomonalactivity should be given to patients with antithyroid drug-induced agranulocytosis who present with severe infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:32:09