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Titolo:
ONCOPROTEIN SIGNALING AND MITOSIS
Autore:
LAIRD AD; SHALLOWAY D;
Indirizzi:
CORNELL UNIV,BIOCHEM MOL & CELL BIOL SECT ITHACA NY 14853 CORNELL UNIV,BIOCHEM MOL & CELL BIOL SECT ITHACA NY 14853
Titolo Testata:
Cellular signalling
fascicolo: 3-4, volume: 9, anno: 1997,
pagine: 249 - 255
SICI:
0898-6568(1997)9:3-4<249:OSAM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CYCLE CONTROL; TRANSCRIPTIONALLY ACTIVE P53; ATAXIA-TELANGIECTASIA GENE; FAMILY TYROSINE KINASES; RAF-1 PROTEIN-KINASE; NIH 3T3 CELLS; MAP KINASE; MAMMALIAN-CELLS; GROWTH ARREST; C-SRC;
Keywords:
ONCOPROTEIN; MITOSIS; CHECKPOINT; TUMOR SUPPRESSOR; KINASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
126
Recensione:
Indirizzi per estratti:
Citazione:
A.D. Laird e D. Shalloway, "ONCOPROTEIN SIGNALING AND MITOSIS", Cellular signalling, 9(3-4), 1997, pp. 249-255

Abstract

Studies on the roles of oncoproteins in cell cycle progression have concentrated on G1 because transformation is frequently associated withloss of G1 checkpoint control. However, it has become evident that G2and mitotic checkpoints are often compromised in transformed cells and that many tumour suppressor proteins and oncoprotein kinases regulate and/or are activated in G2 and M. Disruption of p53 and ATM tumour suppressor protein functions can eliminate G2 and M checkpoints. The Src family kinases are activated in mitosis and collectively play an indispensable role in progression through G2/M. In addition, evidence suggests that Mos and elements of the Ras/Raf/MAPK cascade are also active in mitosis and appear likely to regulate G2 and/or M. Potential targets of these kinases include likely regulators of gene expression and microtubule dynamics such as Sam68 and Oncoprotein 18/strathmin. The ability of some oncoproteins to perturb orderly progression through both G1 and/or S and G2 and/or M is probably important for transformation. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:42:17