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Titolo:
EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology
Autore:
Rong, YQ; Doctrow, SR; Tocco, G; Baudry, M;
Indirizzi:
Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Program, Los Angeles, CA 90089 USA Eukar Inc, Bedford, MA 01730 USA Eukar Inc Bedford MA USA 01730Eukar Inc, Bedford, MA 01730 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 17, volume: 96, anno: 1999,
pagine: 9897 - 9902
SICI:
0027-8424(19990817)96:17<9897:EASSDA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANOTYPIC HIPPOCAMPAL CULTURES; EXCITOTOXICITY IN-VIVO; RAT LIMBIC STRUCTURES; FACTOR-KAPPA-B; KAINIC ACID; INDUCED SEIZURES; FREE-RADICALS; NITRIC-OXIDE; ALZHEIMERS-DISEASE; NMDA-RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Baudry, M Univ So Calif, Neurosci Program, HNB309, Los Angeles, CA 90089 USA Univ So Calif HNB309 Los Angeles CA USA 90089 eles, CA 90089 USA
Citazione:
Y.Q. Rong et al., "EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology", P NAS US, 96(17), 1999, pp. 9897-9902

Abstract

The present study tested the effects of EUK-134, a synthetic superoxide dismutase/catalase mimetic, on several indices of oxidative stress and neuropathology produced in the rat limbic system as a result of seizure activity elicited by systemic kainic acid (KA) administration. Pretreatment of rats with EUK-134 did not modify the latency for or duration of KA-induced seizure activity. It did produce a highly significant reduction in increased protein nitration, activator protein-1 and NF-kappa B-binding activity, and spectrin proteolysis as well as in neuronal damage resulting from seizure activity in limbic structures. These results support the hypothesis that kainate-induced excitotoxicity is caused, at least in part, by the action of reactive oxygen species, Furthermore, they suggest that synthetic superoxide dismutase/catalase mimetics such as EUK-134 might be used to prevent excitotoxic neuronal injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:05:51