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Titolo:
17 beta-estradiol regulation of melanin-concentrating hormone and neuropeptide-E-I contents in cynomolgus monkeys: a preliminary study
Autore:
Viale, A; Kerdelhue, B; Nahon, JL;
Indirizzi:
CNRS, UPR 411, Inst Pharmacol Mol & Cellulaire, F-06500 Valbonne, France CNRS Valbonne France F-06500 Mol & Cellulaire, F-06500 Valbonne, France Fac Pharm, CNRS, EP 1591, Lab Neurobiol Mol & Cellulaire, F-75270 Paris 06, France Fac Pharm Paris France 06 iol Mol & Cellulaire, F-75270 Paris 06, France Eastern Virginia Med Sch, Jones Inst Reprod Med, Norfolk, VA 23507 USA Eastern Virginia Med Sch Norfolk VA USA 23507 Med, Norfolk, VA 23507 USA
Titolo Testata:
PEPTIDES
fascicolo: 5, volume: 20, anno: 1999,
pagine: 553 - 559
SICI:
0196-9781(1999)20:5<553:1BROMH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-LH SURGE; ANTERIOR-PITUITARY; MESSENGER-RNA; PUTATIVE NEUROPEPTIDES; ESTROUS-CYCLE; FEMALE RAT; ALPHA-MSH; BRAIN; GENE; EXPRESSION;
Keywords:
melanin-concentrating hormone (MCH); neuropeptide-E-I (NEI); MCH mRNA expression; monkey brain; estrogen; LH surge in primate; reproduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nahon, JL CNRS, UPR 411, Inst Pharmacol Mol & Cellulaire, 660 Route des Lucioles, F-06500 Valbonne, France CNRS 660 Route des Lucioles Valbonne France F-06500 nne, France
Citazione:
A. Viale et al., "17 beta-estradiol regulation of melanin-concentrating hormone and neuropeptide-E-I contents in cynomolgus monkeys: a preliminary study", PEPTIDES, 20(5), 1999, pp. 553-559

Abstract

Melanin-concentrating hormone (MCH) and neuropeptide-E-I (NEI) regulate several behaviors and neuroendocrine functions in rats. Possible influence ofthese peptides on sexual behavior and reproduction in mammals other than rodents prompted us to investigate: 1) The sites of synthesis of MCH and NEIin the brain of a non-human primate (M. fascicularis); 2) The effect, of 17 beta-estradiol (E-2) benzoate (E2B) on pro-MCH-derived peptide concentrations in the hypothalamus of the ovariectomized (OVX) cynomolgus monkeys (M.fascicularis). Expression of MCH mRNA and peptides was examined by Northern blotting, RT-PCR and RP-HPLC/RIA. Our results demonstrate that the MCH gene is predominantly expressed in hypothalamus of macaque. E2B exposure of OVX monkeys provoked parallel phasic variations in the MCH-immunoreactivity (IR) and NEI-IR. NEI-IR and to a lesser extent MCH-IR, showed a transient increase (associated with the estradiol peak) at 30 h with a final rise of both MCH-IR and NEI-IR observed at the time (72 h post E2B) of the luteinizing hormone (LH) surge. RP-HPLC analysis of peptide extracts revealed the presence, in addition to mature MCH and NEI, of different MCH-IR and NEI-IR forms in the hypothalami of control and E2B-treated monkeys. Taken together,our results indicated that hypothalamic MCH and NEI contents are regulatedafter E2B treatment and they suggest the possible involvement of these peptides in the regulation of the pre-ovulatory midcycle LH surge in primates. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:11:31