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Titolo:
Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics
Autore:
Zhang, WN; Pouzet, B; Jongen-Relo, AL; Weiner, I; Feldon, J;
Indirizzi:
Swiss Fed Inst Technol, Behav Biol Lab, CH-8603 Schwerzenbach, SwitzerlandSwiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland Tel Aviv Univ, Dept Psychol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 sychol, IL-69978 Tel Aviv, Israel
Titolo Testata:
NEUROREPORT
fascicolo: 12, volume: 10, anno: 1999,
pagine: 2533 - 2538
SICI:
0959-4965(19990820)10:12<2533:DOPIFN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENCYCLIDINE-INDUCED DEFICITS; ACOUSTIC STARTLE RESPONSE; PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; SCHIZOPHRENIC-PATIENTS; ANIMAL-MODEL; RAT; GLUTAMATE; DOPAMINE; DRUGS;
Keywords:
animal model; antipsychotics; clozapine; haloperidol; neuroleptics; NMDA; prepulse inhibition; ventral hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J Swiss Fed Inst Technol, Behav Biol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
W.N. Zhang et al., "Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics", NEUROREPORT, 10(12), 1999, pp. 2533-2538

Abstract

THE present study tested the effects of the typical neuroleptic haloperidol and an atypical neuroleptic clozapine on ventral hippocampus stimulation-induced disruption of prepulse inhibition (PPI). Bilateral infusions of 0.7mu g NMDA into the ventral hippocampus disrupted PPI. The impairment of PPI following the infusion was completely normalized 24h after the infusion. This disruption of PPI was antagonized by clozapine (5.0mg/kg), but not by haloperidol (0.2mg/kg). Since disruption of PPI is considered to constitutean animal model of schizophrenia that is related to the deficit of sensorimotor gating observed in schizophrenic patients, these results suggest thatPPI disruption induced by intra-ventral hippocampal infusions of NMDA may serve as an animal model for the selective detection of atypical antipsychotics. NeuroReport 10:2533-2538 (C) 1999 Lippincott Williams & Wilkins.

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Documento generato il 02/04/20 alle ore 06:14:30