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Titolo:
Nitric oxide synthase in trigeminal ganglion cells projecting to the cochlea of rat and guinea pig
Autore:
Riemann, R; Reuss, S;
Indirizzi:
Univ Wurzburg, Dept Otorhinolaryngol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 ryngol, D-97080 Wurzburg, Germany Univ Mainz, Sch Med, Dept Anat, D-55099 Mainz, Germany Univ Mainz Mainz Germany D-55099 Med, Dept Anat, D-55099 Mainz, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 12, volume: 10, anno: 1999,
pagine: 2641 - 2645
SICI:
0959-4965(19990820)10:12<2641:NOSITG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR CERVICAL-GANGLION; AUDITORY BRAIN-STEM; SENSORY GANGLIA; BLOOD-FLOW; NEURONS; COLOCALIZATION; NITROPRUSSIDE; LOCALIZATION; ISOFORMS;
Keywords:
cochlea; Fluoro-Gold; nitric oxide synthase (NOS); retrograde tracing; superior cervical ganglion; trigeminal ganglion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Riemann, R Univ Wurzburg, Dept Otorhinolaryngol, Josef Schneider Str 11, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 11 Wurzburg Germany D-97080
Citazione:
R. Riemann e S. Reuss, "Nitric oxide synthase in trigeminal ganglion cells projecting to the cochlea of rat and guinea pig", NEUROREPORT, 10(12), 1999, pp. 2641-2645

Abstract

NITRIC oxide (NO) influences electrophysiological and morphological parameters of the mammalian cochlea. Recently, the isoform of the NO-producing enzyme neuronal NO synthase (nNOS) has been demonstrated in spiral ganglion cells and olivocochlear neurons. The cochlea is also innervated by fibers stemming from the trigeminal ganglion (TG) and superior cervical ganglion (SCG). Whether these ganglion cells contain nNOS is not known yet. We therefore identified TG and SCG cells upon injection of Fluoro-Gold (FG) into the cochlea and retrograde neuronal transport of FG in rat and guinea pig. Theseganglion cells were investigated for neuronal NOS immunohistochemically. Perikarya labeled by FG were found in the ipsilateral TG and SCG. In both species investigated, a considerable number of FG-labeled TG cells were also nNOS-immunoreactive whereas SCG cells were not. These data, demonstrating the existence of nNOS-containing TG cells that project to the cochlea, provide evidence that these neurons are further sources of nitric oxide in the cochlea. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:38:20