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Titolo:
Modulatory effects of garlic and neem leaf extracts on circulating lipid peroxides and antioxidants during N-methyl-N '-nitro-N-nitrosoguanidine-induced gastric carcinogenesis
Autore:
Arivazhagan, S; Balasenthil, S; Nagini, S;
Indirizzi:
Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India
Titolo Testata:
MEDICAL SCIENCE RESEARCH
fascicolo: 8, volume: 27, anno: 1999,
pagine: 527 - 529
SICI:
0269-8951(199908)27:8<527:MEOGAN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL-CANCER PATIENTS; GLUTATHIONE; QUERCETIN; SELENIUM; CELLS; MICE; RATS;
Keywords:
antioxidants; chemoprevention; garlic; gastric cancer; glutathione; lipid peroxidation; neem; N-methyl-N '-nitro-N-nitrosoguanidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 du, India
Citazione:
S. Arivazhagan et al., "Modulatory effects of garlic and neem leaf extracts on circulating lipid peroxides and antioxidants during N-methyl-N '-nitro-N-nitrosoguanidine-induced gastric carcinogenesis", MED SCI RES, 27(8), 1999, pp. 527-529

Abstract

We have investigated the chemopreventive effects of garlic (Allium sativumLinn) and neem (Azadirachta indica A. Juss) on circulatory lipid peroxidation and antioxidant status during gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in male Wistar rats. Enhanced lipid peroxidation in the circulation of tumour-bearing animals was accompanied by significant decreases in reduced glutathione (GSH) and ascorbic acid concentrations and glutathione peroxidase (GPx) activity. Administration of garlic and neem leaf extracts significantly lowered the formation of lipid peroxides and raised levels of ascorbic acid, GSH and GPx. We speculate that extracts of garlic and neem leaf exert their chemoprotective effects by modulating lipid peroxidation and antioxidant systems. Med Sci Res 27:527-529 (C)1999 Lippincott Williams & Wilkins.

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Documento generato il 22/09/20 alle ore 20:35:18