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Titolo:
MIP-1 alpha and MCP-1 contribute to crescents and interstitial lesions in human crescentic glomerulonephritis
Autore:
Wada, T; Furuichi, K; Segawa-Takaeda, C; Shimizu, M; Sakai, N; Takeda, S; Takasawa, K; Kida, H; Kobayashi, K; Mukaida, N; Ohmoto, Y; Matsushima, K; Yokoyama, H;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 1, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan Kanazawa Univ, Sch Med, Div Blood Purificat, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan Kanazawa Univ, Canc Res Inst, Dept Mol Pharmacol, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan Kanazawa Natl Hosp, Dept Internal Med, Kanazawa, Ishikawa, Japan Kanazawa Natl Hosp Kanazawa Ishikawa Japan ed, Kanazawa, Ishikawa, Japan Kurobe Municipal Hosp, Kurobe, Japan Kurobe Municipal Hosp Kurobe JapanKurobe Municipal Hosp, Kurobe, Japan Ohtsuka Pharmaceut Co Ltd, Cell Technol Inst, Tokushima, Japan Ohtsuka Pharmaceut Co Ltd Tokushima Japan echnol Inst, Tokushima, Japan Univ Tokyo, Sch Med, Dept Mol Prevent Med, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 h Med, Dept Mol Prevent Med, Tokyo 113, Japan
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 3, volume: 56, anno: 1999,
pagine: 995 - 1003
SICI:
0085-2538(199909)56:3<995:MAAMCT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA; LUPUS NEPHRITIS; CHEMOKINETIC PROPERTIES; MESANGIAL CELLS; IGA NEPHROPATHY; URINARY LEVELS; EXPRESSION; DISEASE; CDNA; CYTOKINES;
Keywords:
macrophage inflammatory protein-1 alpha; monocyte chemoattractant protein-1; cellular crescents; rapidly progressive glomerulonephritis; CCR5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Wada, T Kanazawa Univ, Sch Med, Dept Internal Med 1, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 9208641 an
Citazione:
T. Wada et al., "MIP-1 alpha and MCP-1 contribute to crescents and interstitial lesions in human crescentic glomerulonephritis", KIDNEY INT, 56(3), 1999, pp. 995-1003

Abstract

Background. The precise molecular mechanisms of macrophage (M phi) recruitment and activation in crescentic glomerulonephritis remain to be investigated. We hypothesized that locally produced macrophage inflammatory protein (MIP)-1 alpha and monocyte chemoattractant protein (MCP)-1 via the chemokine receptors participate in the pathophysiology of human crescentic glomerulonephritis by recruiting and activating M phi. Methods. We investigated the levels of MIP-1 alpha and MCP-1 by enzyme-linked immunosorbent assay (ELISA) in 20 healthy subjects, 20 patients with crescentic glomerulonephritis, and 41 control patients with various other renal diseases. The presence of MIP-1 alpha, MCP-1, and the cognate chemokine receptor for MIP-1 alpha, CCR5, in the diseased kidneys was evaluated by immunohistochemical and in situ hybridization analyses. Results. MIP-1 alpha-positive cells were mainly detected in crescentic lesions, whereas MCP-1 was mainly in the interstitium. In addition, we detected CCR5-positive cells in diseased glomeruli and interstitium. Urinary MIP-1alpha was detected in crescentic glomerulonephritis, even though it was below detectable levels in healthy subjects and in patients with other renal diseases without crescents. Urinary MIP-1 alpha levels in the patients withcrescentic glomerulonephritis were well correlated with the percentage of cellular crescents and the number of CD68-positive infiltrating cells and CCR5-positive cells in the glomeruli. However, urinary MCP-1 levels were well correlated with the percentage of both total crescents and fibrocellular/fibrous crescents and the number of CD68-positive infiltrating cells in theinterstitium, Moreover, elevated urinary levels of both MIP-1 alpha and MCP-1 dramatically decreased during glucocorticoid therapy-induced convalescence. Conclusions. These observations suggest that locally produced MIP-1 alpha may be involved in the development of cellular crescents in the acute phasevia CCR5 and that MCP-1 may be involved mainly in the development of interstitial lesions in the chronic phase when fibrocellular/fibrous crescents are present, possibly through M phi recruitment and activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 21:55:58