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Titolo:
The relation of putamen and caudate nucleus F-18-Dopa uptake to motor and cognitive performances in Parkinson's disease
Autore:
Broussolle, E; Dentresangle, C; Landais, P; Garcia-Larrea, L; Pollak, P; Croisile, B; Hibert, O; Bonnefoi, F; Galy, G; Froment, JC; Comar, D;
Indirizzi:
Hop Neurol Pierre Wertheimer, Dept Neurol, F-69003 Lyon, France Hop NeurolPierre Wertheimer Lyon France F-69003 l, F-69003 Lyon, France Hop Neurol Pierre Wertheimer, CERMEP Cyclotron Unit, F-69003 Lyon, France Hop Neurol Pierre Wertheimer Lyon France F-69003 t, F-69003 Lyon, France Univ Lyon 1, UPRES EA 1880, F-69365 Lyon, France Univ Lyon 1 Lyon FranceF-69365 n 1, UPRES EA 1880, F-69365 Lyon, France Univ Lyon 1, CNRS UMR 55 42, F-69365 Lyon, France Univ Lyon 1 Lyon France F-69365 1, CNRS UMR 55 42, F-69365 Lyon, France Univ Grenoble 1, Dept Clin & Biol Neurosci, Grenoble, France Univ Grenoble1 Grenoble France Clin & Biol Neurosci, Grenoble, France Hop Neurol Pierre Wertheimer, Lab Neuropsychol Cognit Funct Language & Memory, F-69003 Lyon, France Hop Neurol Pierre Wertheimer Lyon France F-69003 y, F-69003 Lyon, France Hop Neurol Pierre Wertheimer, Dept Neuroradiol, F-69003 Lyon, France Hop Neurol Pierre Wertheimer Lyon France F-69003 l, F-69003 Lyon, France
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 166, anno: 1999,
pagine: 141 - 151
SICI:
0022-510X(19990701)166:2<141:TROPAC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; PROGRESSIVE SUPRANUCLEAR PALSY; MULTIPLE SYSTEM ATROPHY; F-18 DOPA-PET; BASAL GANGLIA; DYSFUNCTION; P300; METABOLISM; COMPONENT; DEMENTIA;
Keywords:
Parkinson's disease; striatum; dopamine; positron emission tomography (PET); [F-18]-6-fluoro-L-Dopa; motor disability; cognitive functions; event-related potentials; principal components analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Broussolle, E Hop Neurol Pierre Wertheimer, Dept Neurol, 59 Blvd Pinel, F-69003 Lyon, France Hop Neurol Pierre Wertheimer 59 Blvd Pinel Lyon France F-69003
Citazione:
E. Broussolle et al., "The relation of putamen and caudate nucleus F-18-Dopa uptake to motor and cognitive performances in Parkinson's disease", J NEUR SCI, 166(2), 1999, pp. 141-151

Abstract

The contribution of striatal (caudate nucleus-putamen) dopaminergic deficiency to the severity of motor signs is well established in Parkinson's disease (PD), while its role in the occurrence of cognitive and mood changes remains unresolved. We therefore measured in 27 non-demented PD patients and 10 age-matched controls striatal uptake of [F-18]-6-fluoro-L-Dopa (F-Dopa) with PET, and mood (Beck depression), memory (Grober-Buschke), frontal executive functions (verbal fluency and Wisconsin card sorting), and attentional processing of sensory stimuli (N2-P3 auditory event-related potentials - ERPs). Locomotor disability of patients was assessed by Hoehn and Yahr score and Unified Parkinson's Disease Rating Scale (UPDRS), ANOVA showed that memory, but neither frontal lobe functions nor ERPs, was significantly altered in PD patients, whereas indices of depression were found only in advanced PD. The F-Dopa rate constant K-i was significantly reduced in the striatum, more in putamen than caudate nucleus, and inversely correlated with disease duration. A significant inverse correlation was found between both putamen and caudate nucleus Ki and Hoehn and Yahr score, and between putamen - but not caudate nucleus K-i - and UPDRS motor score, Principal components analysis (PCA) of PD patients K-i values and mood, cognitive and ERP parameters gave a three-factor solution. Variables contributing to factor 1 were memory score and N2-P3 ERP latencies, those to factor 2 were striatal K-i values, and those to factor 3 frontal executive performances. Depression did not segregate with any variable. Our findings suggest that unlike locomotordisability, cognitive abilities and mood state of non-demented PD patientsare for the most part unrelated to striatal dopaminergic depletion and mayresult from dysfunction of extra-striatal dopaminergic or from non-dopaminergic systems. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 21/01/20 alle ore 07:04:25