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Titolo:
Evaluation of a vancomycin chiral stationary phase in packed capillary supercritical fluid chromatography
Autore:
Donnecke, J; Svensson, LA; Gyllenhaal, O; Karlsson, KE; Karlsson, A; Vessman, J;
Indirizzi:
Astra Hassle AB, Div Analyt Chem, S-43183 Molndal, Sweden Astra Hassle ABMolndal Sweden S-43183 lyt Chem, S-43183 Molndal, Sweden Biomed Ctr, Dept Pharmaceut Analyt Chem, S-75123 Uppsala, Sweden Biomed Ctr Uppsala Sweden S-75123 t Analyt Chem, S-75123 Uppsala, Sweden
Titolo Testata:
JOURNAL OF MICROCOLUMN SEPARATIONS
fascicolo: 7, volume: 11, anno: 1999,
pagine: 521 - 533
SICI:
1040-7685(1999)11:7<521:EOAVCS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; MACROCYCLIC ANTIBIOTICS; BETA-BLOCKERS; CHYROSINE-A; TEMPERATURE; SEPARATIONS; ENANTIOSEPARATIONS; SELECTORS; PRESSURE; COLUMN;
Keywords:
temperature effect; structure analogues; beta-adrenergic blocking agents; amine and methanol modified CO2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Svensson, LA Astra Hassle AB, Div Analyt Chem, S-43183 Molndal, Sweden Astra Hassle AB Molndal Sweden S-43183 3183 Molndal, Sweden
Citazione:
J. Donnecke et al., "Evaluation of a vancomycin chiral stationary phase in packed capillary supercritical fluid chromatography", J MICROCOL, 11(7), 1999, pp. 521-533

Abstract

Vancomycin immobilized on an aldehyde functionalized silica support in packed capillary columns has been used as a chiral stationary phase in supercritical fluid chromatography under subcritical conditions. The use of carbondioxide with methanol as the mobile phase modifier is shown to offer an extended scope of chiral separations compared with reversed-phase liquid chromatography, especially for basic analytes. It could be demonstrated that the chiral recognition of vancomycin for different analytes is based on several kinds of interactions. Large differences in enantioselectivity in a homologous series of local anesthetic compounds indicate that the fit of a host-guest interaction between an analyte and vancomycin could be very precise. Nonlinear van't Hoff plots implied that the enantiomers of metoprolol and the modifiers evaporated from their adsorption sites at different temperatures. (C) 1999 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 01:26:30