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Titolo:
Covalent and non-covalent dissociations of gas-phase complexes of avoparcin and bacterial receptor mimicking precursor peptides studied by collisionally activated decomposition mass spectrometry
Autore:
van der Kerk-van Hoof, A; Heck, AJR;
Indirizzi:
Univ Utrecht, Dept Biomol Mass Spectrometry, NL-3584 CA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CA 3584 CA Utrecht, Netherlands Univ Utrecht, Bijvoet Ctr Biomol Res, Dept Chem, NL-3584 CA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CA 3584 CA Utrecht, Netherlands Univ Utrecht, Inst Pharmaceut Sci, Dept Pharm, NL-3584 CA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CA 3584 CA Utrecht, Netherlands
Titolo Testata:
JOURNAL OF MASS SPECTROMETRY
fascicolo: 8, volume: 34, anno: 1999,
pagine: 813 - 819
SICI:
1076-5174(199908)34:8<813:CANDOG>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
VANCOMYCIN-GROUP ANTIBIOTICS; ALANYL-D-ALANINE; GLYCOPEPTIDE ANTIBIOTICS; NONCOVALENT INTERACTIONS; ENTEROCOCCUS-GALLINARUM; PROTON AFFINITIES; RESISTANCE; BINDING; ENZYME; SEQUENCE;
Keywords:
antibiotics; vancomycin; avoparcin; non-covalent complexes; collisionally activated decomposition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Heck, AJR Univ Utrecht, Dept Biomol Mass Spectrometry, Sorbonnelaan 16, NL-3584 CA Utrecht, Netherlands Univ Utrecht Sorbonnelaan 16 Utrecht Netherlands NL-3584 CA nds
Citazione:
A. van der Kerk-van Hoof e A.J.R. Heck, "Covalent and non-covalent dissociations of gas-phase complexes of avoparcin and bacterial receptor mimicking precursor peptides studied by collisionally activated decomposition mass spectrometry", J MASS SPEC, 34(8), 1999, pp. 813-819

Abstract

The gas-phase stability and reactivity of non-covalent complexes of avoparcin and bacterial receptor mimicking precursor peptides were probed by electrospray ionization mass spectrometry combined with collisionally activateddecomposition (CAD) studies. The order of the gas-phase stabilities of these non-covalent complexes is different from the order of the stabilities ofthe same complexes in solution. The specific stereoselectivity observed innon-covalent binding in solution is not retained in the gas phase. The presence of a lysine residue in the bacterial receptor mimicking precursor peptides appears to promote the gas-phase stabilities of the antibiotic-peptide complexes. Complexes of avoparcin with receptor peptides containing a lysine residue are stabilized in the gas phase to such an extent that CAD of these non-covalent complexes proceeds through a competition between non-covalent and covalent fragmentation pathways. These results indicate clearly that the use of CAD mass spectra for the quantitative characterization of thestability of non-covalent complexes in solution should be applied with extreme caution. Copyright (C) 1999 John Whey & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:00:26