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Titolo:
In vitro evaluation of the amebicidal activity of Buddleia cordata (Loganiaceae, HBK) on several strains of Acanthamoeba
Autore:
Rodriguez-Zaragoza, S; Ordaz, C; Avila, G; Munoz, JL; Arciniegas, A; de Vivar, AR;
Indirizzi:
UNAM, Unidad Biol Tecnol & Prototipos, Microbiol Lab, Tlalnepantla 54090, Estado Mexico, Mexico UNAM Tlalnepantla Estado Mexico Mexico 54090 54090, Estado Mexico, Mexico Inst Quim, Mexico City, DF, Mexico Inst Quim Mexico City DF MexicoInst Quim, Mexico City, DF, Mexico
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 3, volume: 66, anno: 1999,
pagine: 327 - 334
SICI:
0378-8741(199909)66:3<327:IVEOTA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; INFECTION; AMEBAS;
Keywords:
Acanthamoeba; antiamebic compounds; Buddleia; free-living amoebae; susceptibility test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Rodriguez-Zaragoza, S UNAM, Unidad Biol Tecnol & Prototipos, Microbiol Lab, Campus Iztacala,Ave Barrios S-N, Tlalnepantla 54090, Estado Mexico, Mexico UNAM Campus Iztacala,Ave Barrios S-N Tlalnepantla Estado Mexico Mexico 54090
Citazione:
S. Rodriguez-Zaragoza et al., "In vitro evaluation of the amebicidal activity of Buddleia cordata (Loganiaceae, HBK) on several strains of Acanthamoeba", J ETHNOPHAR, 66(3), 1999, pp. 327-334

Abstract

Infectious diseases produced by free-living amoebae from the genus Acanthamoeba have been recently recognized. The need for antiamebic compounds is urgent as the occurrence of these diseases is being registered more frequently since the late sixties. We screened the aqueous and methanolic extract of a plant used by folk medicine (Buddleia cordata) against eye and skin inflammation for antiamebic activity. We tested the extracts on 29 strains of free-living amoebae, with the result that they were amebostatic for 14 and 15 strains: respectively. We obtained linarin and vanillic acid from the extracts, but only linarin was amebostatic to all the strains and vanillic acid had no activity. However, acetyl vanillic acid had similar effects on amoebae to linarin. Threshold values of these two active compounds ranged from 31.25 mu g/ml to 4 mg/ml and from 31.25 mu g/ml to 8 mg/ml for linarin and acetyl vanillic acid, respectively. These differences in threshold valueswere observed even on several strains belonging to the same species (as inthe case of A. castellanii and A. polyphaga) indicating the need of susceptibility testing for each clinical isolate of free-living amoebae. (C) 1999Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:37:33