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Titolo:
Auditory brainstem: Development and plasticity of GAP-43 mRNA expression in the rat
Autore:
Illing, RB; Cao, QL; Forster, CR; Laszig, R;
Indirizzi:
Univ Freiburg, HNO Klin, Dept Otorhinolaryngol, Neurobiol Res Lab, D-79106Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 Res Lab, D-79106Freiburg, Germany
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 2, volume: 412, anno: 1999,
pagine: 353 - 372
SICI:
0021-9967(19990920)412:2<353:ABDAPO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHATASE-LABELED PROBE; ADULT-RAT; PROTEIN GAP-43; MESSENGER-RNA; POSTNATAL-DEVELOPMENT; REACTIVE SYNAPTOGENESIS; TRANSPORTED PROTEINS; INSITU HYBRIDIZATION; INFERIOR COLLICULUS; PHOSPHOPROTEIN B-50;
Keywords:
auditory system; superior olive; cochlear nucleus; inferior colliculus; in situ hybridization; cochleotomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Illing, RB Univ Freiburg, HNO Klin, Dept Otorhinolaryngol, Neurobiol Res Lab, Killianst 5, D-79106 Freiburg, Germany Univ Freiburg Killianst 5 Freiburg Germany D-79106 rg, Germany
Citazione:
R.B. Illing et al., "Auditory brainstem: Development and plasticity of GAP-43 mRNA expression in the rat", J COMP NEUR, 412(2), 1999, pp. 353-372

Abstract

Expression of the growth and plasticity associated protein GAP-43 is closely related to synaptogenesis and synaptic remodeling in the developing as well as in the mature nervous system. We have studied the postnatal development of GAP-43 mRNA expression in the auditory brainstem and determined the time course of its reexpression following deafening through cochlear ablation using a digoxigenin-coupled mRNA probe. By the first postnatal day, GAP-43 mRNA was expressed at high levels in all auditory brainstem nuclei. But whereas GAP-43 mRNA is almost entirely lost in most of these nuclei in the adult animal, significant levels of this molecule are retained in the inferior colliculus and, most notably, in the lateral and medial superior olivary nucleus. As a consequence of unilateral cochleotomy, GAP-43 mRNA rose dramatically in some neurons of the ipsilateral lateral superior olive, whereas the hybridization signal decreased in others. Using double staining protocols, we found that those olivary neurons that increase their level of GAP-43 mRNA appear to be identical with the cells developing strong GAP-43 immunoreactivity after cochleotomy. By combining axonal tracing with in situ hybridization, we proved that at least some of the cells with increased levels of GAP-43 mRNA and protein are the cells of origin of olivocochlear projections. A substantial decrease of the level of GAP-43 mRNA took place in the inferiorcolliculus contralateral to the lesioned cochlea. Our results led us to suggest that neurons in the superior olivary complex may play a crucial role in orchestrating auditory brainstem plasticity. J. Comp. Neurol. 412:353-372, 1999. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 15/07/20 alle ore 08:45:07