Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Acute hypotensive, natriuretic, and hormonal effects of nifedipine in salt-sensitive and salt-resistant black normotensive and hypertensive subjects
Autore:
Damasceno, A; Santos, A; Pestana, M; Serrao, P; Caupers, P; Soares-da-Silva, P; Polonia, J;
Indirizzi:
Fac Med Porto, Unidade Farmacol Clin, P-4200 Porto, Portugal Fac Med Porto Porto Portugal P-4200 armacol Clin, P-4200 Porto, Portugal Univ Eduardo Mondlane, Fac Med, Maputo, Mozambique Univ Eduardo Mondlane Maputo Mozambique ne, Fac Med, Maputo, Mozambique Fac Med Porto, Unidade Nefrol, P-4200 Porto, Portugal Fac Med Porto Porto Portugal P-4200 idade Nefrol, P-4200 Porto, Portugal Fac Med Porto, Inst Farmacol & Terapeut, P-4200 Porto, Portugal Fac Med Porto Porto Portugal P-4200 l & Terapeut, P-4200 Porto, Portugal
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 3, volume: 34, anno: 1999,
pagine: 346 - 353
SICI:
0160-2446(199909)34:3<346:AHNAHE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINERGIC SYSTEM ACTIVITY; DIETARY-SODIUM; BLOOD-PRESSURE; CALCIUM; RESPONSES; INFUSION; BALANCE; RAT;
Keywords:
hypertension in blacks; salt-sensitive; salt-resistant; nifedipin; natriuresis; dopaminergic system; renin; aldosterone; ambulatory monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Polonia, J Fac Med Porto, Unidade Farmacol Clin, P-4200 Porto, Portugal Fac Med Porto Porto Portugal P-4200 n, P-4200 Porto, Portugal
Citazione:
A. Damasceno et al., "Acute hypotensive, natriuretic, and hormonal effects of nifedipine in salt-sensitive and salt-resistant black normotensive and hypertensive subjects", J CARDIO PH, 34(3), 1999, pp. 346-353

Abstract

In a randomized double-blind study, we compared the short-term effects of nifedipine (10 mg 3 x daily for 1 day) versus placebo on 24-h blood pressure, diuresis, natriuresis, urinary excretion of dopamine and metabolites, and on plasma renin activity (PRA) and plasma aldosterone levels in 18 black hypertensive (HT) patients [eight salt-resistant (HT-SR) and 10 salt-sensitive (HT-SS)], and in 20 black normotensive (NT) subjects (12 NT-SR and eight NT-SS) who were studied randomly with both a high- (HS) and a low-salt (LS) diet. In comparison to placebo, nifedipine significantly decreased 24-h mean BP in all groups either with HS or LS diets (all p < 0.05). With HS, greater hypotensive effects were achieved in WT-SS (-10 +/- 2 mm Hg) versus NT-SR (-3 +/- 1 mm Hg; p < 0.05) and in WT-SS (-18 +/- 2 mm Hg) versus MT-SR (-12 +/- 2 mm Hg; p < 0.05). In NT-SS and HT-SS. nifedipine induced greater (p < 0.05) BP decrease with HS (-10 +/- 2 and -18 +/- 2 mm Hg) than withLS (-3 +/- 1 and -9 +/- 1 mm Hg, respectively), whereas in NT-SR and MT-SR, the hypotensive effect did not differ between HS and LS. Nifedipine versus placebo significantly increased natriuresis and fractional excretion of sodium in all groups only with HS (p < 0.05) but not with LS diets. Only in HT-SS were the hypotensive and natriuretic effects of nifedipine significantly correlated (r = -0.77; p < 0.01). Nifedipine produced a similar increase of the urinary excretion of dopamine, L-DOPA, and of DOPAC in all subjects, which did not correlate with hypotensive and natriuretic effects. Nifedipine did not modify plasma levels of renin and of aldosterone except in NT-SS with HS, in whom nifedipine increased PRA levels (p < 0.05). We concludethat although nifedipine reduces BP in all groups of NT and HT with LS andI-IS diets, the effect is greater in salt-sensitive subjects with HS. Although in HT-SS with HS, the short-term natriuretic response to nifedipine may contribute to its hypotensive effects, the diuretic-natriuretic effect ofnifedipine is not necessary for the expression of its hypotensive effect. Moreover, it is unlikely that any short-term effects of nifedipine either on the renal dopaminergic system or on the secretion of aldosterone explain nifedipine short-term hypotensive and diuretic-natriuretic effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:46:53