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Titolo:
DISPOSITION OF ATOVAQUONE IN HUMANS
Autore:
ROLAN PE; MERCER AJ; TATE E; BENJAMIN I; POSNER J;
Indirizzi:
UNIV MANCHESTER,MANCHESTER SCI PK MANCHESTER M15 6SH LANCS ENGLAND WELLCOME RES LABS,DEPT CLIN PHARMACOL BECKENHAM BR3 3BS KENT ENGLAND UNIV LONDON KINGS COLL HOSP,DEPT SURG LONDON SE4 9RS ENGLAND
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 6, volume: 41, anno: 1997,
pagine: 1319 - 1321
SICI:
0066-4804(1997)41:6<1319:DOAIH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
P.E. Rolan et al., "DISPOSITION OF ATOVAQUONE IN HUMANS", Antimicrobial agents and chemotherapy, 41(6), 1997, pp. 1319-1321

Abstract

Atovaquone is an antiprotozoal compound with good in vitro stability against metabolic inactivation. Previous human studies which did not involve radiolabelling had not accounted for a substantial proportion of the dose. The possible metabolism of atovaquone in men was examined in a radiolabelling study involving four healthy male volunteers. Radioactivity was eliminated almost exclusively via the feces. All radioactivity in plasma, urine, and feces was accounted for by atovaquone, with no evidence of metabolites. Radiolabelled atovaquone was administered to a patient with an indwelling biliary tube after surgery. Biliaryradioactivity was approximately 10- to 40-fold higher than that in plasma and was accounted for by atovaquone. Atovaquone is not significantly metabolized in humans but is excreted into bile against a high concentration gradient.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:54:08