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Titolo:
Distribution of BDNF, NT-3 and NT-4 in the developing auditory brainstem
Autore:
Hafidi, A;
Indirizzi:
Fac Med Clermont Ferrand, INSERM, Unite 384, F-63001 Clermont Ferrand, France Fac Med Clermont Ferrand Clermont Ferrand France F-63001 Ferrand, France
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
fascicolo: 4, volume: 17, anno: 1999,
pagine: 285 - 294
SICI:
0736-5748(199907)17:4<285:DOBNAN>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; NERVE GROWTH-FACTOR; ADULT-RAT FOREBRAIN; NEURONS IN-VIVO; NEUROTROPHIC FACTOR; RECEPTOR GENE; INFERIOR COLLICULUS; TARGETED DISRUPTION; CORTICAL-NEURONS; COCHLEAR NUCLEUS;
Keywords:
neurotrophins; cochlear nucleus; lateral superior olive; medial superior olive; medial nucleus of the trapezoid body; inferior colliculus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Hafidi, A Fac Med Clermont Ferrand, INSERM, Unite 384, 28 Pl Henri-Dunant,F-63001 Clermont Ferrand, France Fac Med Clermont Ferrand 28 Pl Henri-Dunant Clermont Ferrand France F-63001
Citazione:
A. Hafidi, "Distribution of BDNF, NT-3 and NT-4 in the developing auditory brainstem", INT J DEV N, 17(4), 1999, pp. 285-294

Abstract

This study describes the developmental expression of three neurotrophins, brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3) and neurotrophin (NT-4) in the rat auditory brainstem using immunohistochemistry. At postnatal day 0 (PND 0), neurotrophins expression was virtually absent from all auditory nuclei in the brainstem, even though some positive neurons were observed in the mesencephalic trigeminal nucleus at this age. However, BDNF, NT-3 and NT-4 positive neurons were observed in most brainstem auditorynuclei by PND 6. At the following stages, there was a general increase in the intensity of the neurotrophins immunoreactivity and BDNF labeling was particularly prominent in most cochlear nucleus neurons. A differential pattern of staining emerged in cochlear nucleus subdivisions, with more intensestaining present in the ventral part. The superior olivary complex nuclei followed a similar pattern of BDNF staining compared to the cochlear nucleus. In the adult, BDNF heavily labeled most neurons of the superior olivary nuclei and moderately labeled neurons of the inferior colliculus (IC). NT-3and NT-4 showed a similar pattern of staining in most auditory brainstem nuclei. The first staining was observed by PND 6 in some neuronal cell bodies. NT-3 and NT-4 immunoreactivity increased in the following stages and in the adult moderate labelings were observed in most neurons of the cochlear nucleus, the superior olivary nuclei and the IC. These results show that neurotrophins are expressed 1 week before the onset of hearing and the increase of their expressions correlate with the appearance of sound-evoked activity in the system. The temporal distribution of neurotrophins does not correlate with neuronal birth, axonal outgrowth or the formation of connection in the auditory structures, suggesting a role primarily in the maintenance and/or modulation of postnatal and adult functions. (C) 1999 ISDN. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:05:48