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Titolo:
Mother-to-child transmission of human T-cell-leukemia/lymphoma virus type I: Implication of high antiviral antibody titer and high proviral load in carrier mothers
Autore:
Ureta-Vidal, A; Angelin-Duclos, C; Tortevoye, P; Murphy, E; Lepere, JF; Buigues, RP; Jolly, N; Joubert, M; Carles, G; Pouliquen, JF; de The, G; Moreau, JP; Gessain, A;
Indirizzi:
Inst Pasteur, Dept Retrovirus, SIDA, Unite Epidemiol Virus Oncogenes, F-75724 Paris 15, France Inst Pasteur Paris France 15 l Virus Oncogenes, F-75724 Paris 15, France Inst Pasteur, Lab Retrovirol, Cayenne, French Guiana Inst Pasteur Cayenne French Guiana b Retrovirol, Cayenne, French Guiana Univ Calif San Francisco, Dept Lab Med Med & Epidemiol Biostat, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA tat, San Francisco, CA USA Ctr Prevent Maternelle & Infantile, Maripasoula, French Guiana Ctr PreventMaternelle & Infantile Maripasoula French Guiana nch Guiana Ctr Hosp Andre Bouron, Serv Gynecol Obstet, St Laurent Du Maroni, French Guiana Ctr Hosp Andre Bouron St Laurent Du Maroni French Guiana French Guiana
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 6, volume: 82, anno: 1999,
pagine: 832 - 836
SICI:
0020-7136(19990909)82:6<832:MTOHTV>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; BLOOD MONONUCLEAR-CELLS; HTLV-I; FRENCH-GUIANA; MATERNAL TRANSMISSION; PERIPHERAL-BLOOD; BREAST-MILK; INFECTION; POPULATION; PREVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Gessain, A Inst Pasteur, Dept Retrovirus, SIDA, Unite Epidemiol Virus Oncogenes, 28 Rue Dr Roux, F-75724 Paris 15, France Inst Pasteur 28 Rue Dr RouxParis France 15 4 Paris 15, France
Citazione:
A. Ureta-Vidal et al., "Mother-to-child transmission of human T-cell-leukemia/lymphoma virus type I: Implication of high antiviral antibody titer and high proviral load in carrier mothers", INT J CANC, 82(6), 1999, pp. 832-836

Abstract

In order to gain new insights into the risk factors influencing human-T-cell-leukemia/lymphoma-virus-type-I (HTLV-I) mother-to child transmission, a retrospective study of HTLV-I infection among children born to HTLV-I-seropositive women was carried out in a highly HTLV-I-endemic population of African origin living in French Guyana. The study covered 81 HTLV-I-seropositive mothers and their 216 children aged between 18 months old and 12 years old. All plasma samples were tested for the presence of HTLV-I antibodies by ELISA, immunofluorescence assay and Western blot. HTLV-I provirus was detected, in the DNA extracted from peripheral-blood mononuclear cells, by polymerase chain reaction (PCR) using primers specific for 3 different HTLV-I genomic regions (LTR, gag and pX) and quantified by a competitive PCR assay. Out of the 216 children, 21 were found to be HTLV-I-seropositive, giving a crude HTLV-I transmission rate of 9.7%, while among the 180 breast-fed children 10.6% were HTLV-I seropositive. Perfect concordance between serological and PCR results was observed, and none of the 195 HTLV-I-negative children was found HTLV-l-positive by PCR. In conditional (by family) logistic-regression models, HTLV-I seropositivity in children was associated with an elevated maternal anti-HTLV-I-antibody titer (OR 2.2, p = 0.0013), a high maternal HTLV-I proviral load (OR 2.6, p = 0.033) and child's gender, girls being more frequently HTLV-l-infected than boys: OR 3.6, p = 0.0077 in the model including maternal anti-HTLV-I-antibody titer and OR 4.1, p = 0.002 in the model including the maternal HTLV-I proviral load. (C) 1999 Wiley-Liss,Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 03:04:55