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Titolo:
Protective effect of anti-P-selectin monoclonal antibody in lipopolysaccharide-induced lung hemorrhage
Autore:
Ohnishi, M; Imanishi, N; Tojo, SJ;
Indirizzi:
Sumitomo Pharmaceut Co Ltd, Res Ctr, Konohana Ku, Osaka 5540022, Japan Sumitomo Pharmaceut Co Ltd Osaka Japan 5540022 Ku, Osaka 5540022, Japan
Titolo Testata:
INFLAMMATION
fascicolo: 5, volume: 23, anno: 1999,
pagine: 461 - 469
SICI:
0360-3997(199910)23:5<461:PEOAMA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL REPERFUSION INJURY; RESPIRATORY-DISTRESS SYNDROME; IN-VIVO; PLASMA; RATS; OLIGOSACCHARIDE; DEFICIENT; ENDOTOXIN; ISCHEMIA; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Ohnishi, M Sumitomo Pharmaceut Co Ltd, Res Ctr, Konohana Ku, 1-98 Kasugadenaka 3 Chome, Osaka 5540022, Japan Sumitomo Pharmaceut Co Ltd 1-98 Kasugadenaka 3 Chome Osaka Japan 5540022
Citazione:
M. Ohnishi et al., "Protective effect of anti-P-selectin monoclonal antibody in lipopolysaccharide-induced lung hemorrhage", INFLAMMATIO, 23(5), 1999, pp. 461-469

Abstract

Excessive leukocyte accumulation is involved in the pathogenesis of the sepsis-induced acute lung injury. Selectins are essential to the interaction between leukocytes and endothelial cells. In this report, we investigated the role of selectins in the severe lung injury induced by lipopolysaccharide (LPS). Significant lung hemorrhage was observed 24 h after the intravenous administration of LPS (1 mg/kg). First, we evaluated the effect of sialylLewis X-oligosaccharide (SLeX-OS), a derivative of sialyl Lewis X which isone of the ligands for E-, P- and L-selectins. The treatment with SLeX-OS (26.5 mg/kg iv bolus + 19.8 mg/kg iv infusion) resulted in a decrease of lung hemorrhage by 49.5% (P < 0.05 versus the control group). Second, we tested the effect of anti-P-selectin monoclonal antibody (MAb), PB1.3, to investigate the role of P-selectin. The bolus administration of PB 1.3 at a doseof 5 mg/kg attenuated the lung hemorrhage by 74.6% (P < 0.05 versus the control group). In addition, we also detected an increase of soluble P-selectin in plasma 24 h after the injection of LPS. These results suggest that P-selectin has a substantial role in the pathogenesis of the lung injury induced by LPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:56:45