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Titolo:
Role of complement receptors in uptake of Mycobacterium avium by macrophages in vivo: evidence from studies using CD18-deficient mice
Autore:
Bermudez, LE; Goodman, J; Petrofsky, M;
Indirizzi:
Calif Pacific Med Ctr, Res Inst, Kuzell Inst Arthrit & Infect Dis, San Francisco, CA 94115 USA Calif Pacific Med Ctr San Francisco CA USA 94115 Francisco, CA 94115 USA Univ Calif San Francisco, Dept Pediat, Electron Microscopy Lab, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 9, volume: 67, anno: 1999,
pagine: 4912 - 4916
SICI:
0019-9567(199909)67:9<4912:ROCRIU>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR NECROSIS FACTOR; MEDIATED UPTAKE; TUBERCULOSIS; GROWTH; CELLS; INFECTION; ABILITY; PHAGOCYTOSIS; INVASION; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Bermudez, LE Calif Pacific Med Ctr, Res Inst, Kuzell Inst Arthrit & InfectDis, 2200 Webster St,Suite 305, San Francisco, CA 94115 USA Calif Pacific Med Ctr 2200 Webster St,Suite 305 San Francisco CA USA 94115
Citazione:
L.E. Bermudez et al., "Role of complement receptors in uptake of Mycobacterium avium by macrophages in vivo: evidence from studies using CD18-deficient mice", INFEC IMMUN, 67(9), 1999, pp. 4912-4916

Abstract

Mycobacterium avium is an intracellular pathogen that has been shown to invade macrophages by using complement receptors in vitro, but mycobacteria released from one cell can enter a second macrophage by using receptors different from complement receptors. Infection of CD18 (beta(2) integrin) knockout mice and the C57 BL/6 control mice led to comparable levels of tissue infection at 1 day, 2 days, 1 week and 3 weeks following administration of bacteria. A histopathological study revealed similar granulomatous lesions in the two mouse strains, with comparable numbers of organisms. In addition,transmission electron microscopy of spleen tissues from both strains of mice showed bacteria inside macrophages. Our in vivo findings support the hypothesis that M. avium in the host is likely to use receptors other than CR3and CR4 receptors to enter macrophages with increased efficiency.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:22:47