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Titolo:
Antiphosphorylcholine antibody levels are elevated in humans with periodontal diseases
Autore:
Schenkein, HA; Gunsolley, JC; Best, AM; Harrison, MT; Hahn, CL; Wu, JH; Tew, JG;
Indirizzi:
Virginia Commonwealth Univ, Clin Res Ctr Periodontal Dis, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 9, volume: 67, anno: 1999,
pagine: 4814 - 4818
SICI:
0019-9567(199909)67:9<4814:AALAEI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY-ONSET PERIODONTITIS; G SUBCLASS CONCENTRATIONS; STREPTOCOCCUS-PNEUMONIAE; C-POLYSACCHARIDE; TEICHOIC-ACID; PHOSPHORYLCHOLINE; SMOKING; LIPOPOLYSACCHARIDE; HAEMOPHILUS; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Schenkein, HA Virginia Commonwealth Univ, Sch Dent, MCV Stn Box 980566, Richmond, VA 23298 USA Virginia Commonwealth Univ MCV Stn Box 980566 RichmondVA USA 23298
Citazione:
H.A. Schenkein et al., "Antiphosphorylcholine antibody levels are elevated in humans with periodontal diseases", INFEC IMMUN, 67(9), 1999, pp. 4814-4818

Abstract

Human immunoglobulin G2 (IgG2) serum concentrations and the IgG2 antibody response to Actinobacillus actinomycetemcomitans can be influenced by genes, by environmental factors such as smoking, and by periodontal disease status. Examination of the IgG2 response to phosphorylcholine (PC), a response thought to be mainly induced by the C polysaccharide of Streptococcus pneumoniae, suggested that periodontal disease status was also associated with this response. This prompted the hypothesis that PC is an important oral antigen associated with organisms in the periodontal flora and that anti-PC antibody is elevated as a consequence of periodontal disease. Subjects in various periodontal disease diagnostic categories in which attachment loss is exhibited were tested for anti-PC in serum. Those with adult periodontitis,localized juvenile periodontitis, generalized early onset periodontitis, and gingival recession all had similar levels of anti-PC IgG2 serum antibodywhich were significantly greater than in the group of subjects with no attachment loss. Analysis of plaque samples from subgingival and supragingivalsites in all diseases categories for reactivity with the anti-PC specific monoclonal antibody TEPC-15 revealed that a substantial proportion of the bacteria in dental plaque (30 to 40%) bear PC antigen; this antigen was not restricted to morphotypes resembling only cocci but was also present on rods and branched filamentous organisms. We found that S. mitis, S, oralis, and S, sanguis, as well as oral actinomycetes, including A. viscosus, A. odontolyticus, and A. israelii, incorporated substantial amounts of [H-3]choline from culture media. Further analysis of antigens derived from these organisms by Western blot indicated that S. oralis, S. sanguis, A. viscosus, A. odontolyticus, and A. israelii contained TEPC-15-reactive antigens, The data show that many commonly occurring bacterial species found in dental plaque contain PC antigen and that immunization with plaque-derived PC antigens as a consequence of inflammation and periodontal attachment loss may influence systemic anti-PC antibody concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:30:07