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Titolo:
Molecular mechanism for the spontaneous generation of pigmentless Porphyromonas gingivalis mutants
Autore:
Chen, W; Kuramitsu, HK;
Indirizzi:
SUNY Buffalo, Dept Oral Biol, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 , Dept Oral Biol, Buffalo, NY 14214 USA
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 9, volume: 67, anno: 1999,
pagine: 4926 - 4930
SICI:
0019-9567(199909)67:9<4926:MMFTSG>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEINASE LYS-GINGIPAIN; CYSTEINE PROTEINASE; ARG-GINGIPAIN; HEMOGLOBIN-BINDING; PROTEASE ACTIVITY; DIRECT REPEATS; GENE; BACTEROIDES; VIRULENCE; ACCUMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kuramitsu, HK SUNY Buffalo, Dept Oral Biol, 3435 Main St, Buffalo, NY 14214 USA SUNY Buffalo 3435 Main St Buffalo NY USA 14214 NY 14214 USA
Citazione:
W. Chen e H.K. Kuramitsu, "Molecular mechanism for the spontaneous generation of pigmentless Porphyromonas gingivalis mutants", INFEC IMMUN, 67(9), 1999, pp. 4926-4930

Abstract

Porphyromonas gingivalis is one of the pathogens associated with periodontal diseases, and its protease activity has been implicated as an important virulence factor. Kgp is the major Lys-gingipain protease of P. gingivalis and appears to be involved not only in enzyme activity but also in hemagglutination and the pigmented phenotype due to heme accumulation and/or hemoglobin binding. However, little information concerning the molecular mechanism for the spontaneous generation of pigmentless P. gingivalis mutants is currently available. In this study, several spontaneous pigmentless mutants of P. gingivalis were isolated and characterized. The results revealed that a portion of the kgp gene had been deleted from the chromosomes of the pigmentless mutants. This deletion appears to result from recombination betweenthe highly homologous DNA sequences encoding the adhesin domains of the tandemly arranged hagA and kgp genes on the chromosomes of P. gingivalis strains.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:05:29