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Titolo:
Changes in relationship between mitochondrial oxygen consumption and pyridine nucleotide levels in rat allografted liver
Autore:
Yagi, T; Kishida, A; Kodama, M; Saeki, Y;
Indirizzi:
Shiga Univ Med Sci, Dept Surg 1, Shiga 5202192, Japan Shiga Univ Med Sci Shiga Japan 5202192 Dept Surg 1, Shiga 5202192, Japan Shiga Univ Med Sci, Dept Basic Sci Hlth & Nursing, Shiga 5202192, Japan Shiga Univ Med Sci Shiga Japan 5202192 h & Nursing, Shiga 5202192, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 3, volume: 15, anno: 1999,
pagine: 181 - 191
SICI:
1386-6346(199908)15:3<181:CIRBMO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; NITRIC-OXIDE; REJECTION; INHIBITION; GRAFT;
Keywords:
liver transplantation; rat liver mitochondria; oxidative phosphorylation; NAD(P)H fluorescence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Yagi, T Shiga Univ Med Sci, Dept Surg 1, Sete Tsukinowa Cho, Shiga 5202192, Japan Shiga Univ Med Sci Sete Tsukinowa Cho Shiga Japan 5202192 , Japan
Citazione:
T. Yagi et al., "Changes in relationship between mitochondrial oxygen consumption and pyridine nucleotide levels in rat allografted liver", HEPATOL RES, 15(3), 1999, pp. 181-191

Abstract

Mitochondrial function in transplanted liver was studied using rat orthotopic liver transplantation (OLT) models. Rats were divided into three groups: (1) Group 1, untreated ACI rats; (2) Group 2, Lewis recipients of ACI livers 24 h after OLT; (3) Group 3, Lewis recipients of ACI livers on postoperative day (POD) 5. Rat liver mitochondria were prepared to evaluate oxygen consumption (QO(2)) and NADH levels during state 3 respiration, simultaneously. The linear relationship between QO(2) and NADH levels in slate 3 mitochondria was maintained in each group, where X was the NADH level and Y was QO(2): group 1 Y = 1.42X - 19.1, group 2, Y = 1.84X - 18.0, group 3, Y = 0.71X - 4.17. Plasma levels of nitric oxide (NO) metabolises were also measured as early plasma markers of the initiation of acute rejection and significant elevation in levels of plasma NO were associated with Group 3. The activity of the mitochondrial electron transport chain was enhanced 24 h afterOLT and suppressed in the stage of acute rejection of POD 5. Nitric oxide might bt: one of the causes of the mitochondrial inhibition. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:47:31