Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Leiomyosarcoma of the uterus: A clinicopathologic multicenter study of 71 cases
Autore:
Mayerhofer, K; Obermair, A; Windbichler, G; Petru, E; Kaider, A; Hefler, L; Czerwenka, K; Leodolter, S; Kainz, C;
Indirizzi:
Univ Vienna, Sch Med, Dept Gynecol & Obstet, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 necol & Obstet, A-1010 Vienna, Austria Univ Innsbruck Hosp, Dept Gynecol & Obstet, Innsbruck, Austria Univ Innsbruck Hosp Innsbruck Austria ecol & Obstet, Innsbruck, Austria Univ Hosp Graz, Dept Gynecol & Obstet, Graz, Austria Univ Hosp Graz GrazAustria Graz, Dept Gynecol & Obstet, Graz, Austria Univ Vienna, Sch Med, Dept Med Comp Sci, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 t Med Comp Sci, A-1090 Vienna, Austria Univ Vienna, Sch Med, Dept Gynecopathol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 t Gynecopathol, A-1090 Vienna, Austria
Titolo Testata:
GYNECOLOGIC ONCOLOGY
fascicolo: 2, volume: 74, anno: 1999,
pagine: 196 - 201
SICI:
0090-8258(199908)74:2<196:LOTUAC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE TUMORS; UTERINE LEIOMYOSARCOMA; PROGNOSTIC FACTORS; FEATURES; NEOPLASMS; SARCOMAS; STAGE;
Keywords:
uterine leiomyosarcoma; prognostic factors; mitotic count; vascular space involvement; stage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Mayerhofer, K Univ Vienna, Sch Med, Dept Gynecol & Obstet, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 , A-1010 Vienna, Austria
Citazione:
K. Mayerhofer et al., "Leiomyosarcoma of the uterus: A clinicopathologic multicenter study of 71 cases", GYNECOL ONC, 74(2), 1999, pp. 196-201

Abstract

Objective. The aim of this study was to evaluate the behavior of uterine leiomyosarcomas in relation to their clinical and pathologic features and toidentify possible prognostic factors. Methods. Seventy-one patients with histologically proven uterine leiomyosarcoma were included in the analysis. Leiomyosarcomas were defined as uterine smooth-muscle tumors with five or more mitoses per 10 high-power fields and cytologic atypia. Cox proportional hazards regression model was used to identify independent prognostic factors. Results. The median follow-up time was 108 months; 5-year overall survivalrate was 65%. Evaluating the correlation between several clinicopathologicparameters, tumors with vascular space involvement had a statistically significantly higher stage than tumors without vasular space involvement (P = 0.015). In a univariate Cox model early tumor stage (P < 0.0001), age <50 years (P < 0.0001), low mitotic count (P = 0.05), and the absence of vascular space involvement (P < 0.0005) were associated with good prognosis. In a multivariate analysis age (P = 0.002), tumor stage (P = 0.004), vascular space involvement (P = 0.003), and mitotic count in stage I tumors (P = 0.002) were found to be independent parameters for good prognosis in patients with uterine leiomyosarcoma. Conclusion. Early tumor stage, age <50 years, and absence of vascular space involvement were independently associated with good prognosis, Mitotic count was detected to be a strong prognostic parameter in early tumor stage, but failed to act as an independent prognostic parameter in patients with tumor stage II-IV disease. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:47:31