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Titolo:
Peripheral markers of oxidative stress in Parkinson's disease. The role ofL-DOPA
Autore:
Martignoni, E; Blandini, F; Godi, L; Desideri, S; Pacchetti, C; Mancini, F; Nappi, G;
Indirizzi:
Univ Pavia, Neurol Inst C Mondino, Lab Funct Neurochem, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 Lab Funct Neurochem, I-27100 Pavia, Italy Univ Pavia, Neurol Inst C Mondino, Ctr Parkinsons Dis & Movement Disorders, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 Movement Disorders, I-27100 Pavia, Italy
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 3-4, volume: 27, anno: 1999,
pagine: 428 - 437
SICI:
0891-5849(199908)27:3-4<428:PMOOSI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL COMPLEX-I; PERFORMANCE LIQUID-CHROMATOGRAPHY; SALICYLATE HYDROXYLATION PRODUCTS; SUPEROXIDE-DISMUTASE ACTIVITY; MESENCEPHALIC CELL-CULTURES; RESPIRATORY-CHAIN ACTIVITY; ELECTRON-TRANSPORT CHAIN; FREE-RADICAL FORMATION; SUBSTANTIA-NIGRA; ELECTROCHEMICAL DETECTION;
Keywords:
platelets; free radicals; dihydroxybenzoates; superoxide dismutase; Parkinson's disease; L-DOPA; 3-O-methyldopa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Blandini, F Univ Pavia, Neurol Inst C Mondino, Lab Funct Neurochem, Via Palestro 3, I-27100 Pavia, Italy Univ Pavia Via Palestro 3 Pavia Italy I-27100 00 Pavia, Italy
Citazione:
E. Martignoni et al., "Peripheral markers of oxidative stress in Parkinson's disease. The role ofL-DOPA", FREE RAD B, 27(3-4), 1999, pp. 428-437

Abstract

Oxidative stress plays a central role in the pathogenesis of Parkinson's disease (PT). L-DOPA, the gold standard in PD therapy, may paradoxically contribute to the progression of the disease because of its pra-oxidant properties. The issue, however, is controversial. In this study, we evaluated peripheral markers of oxidative stress in normal subjects, unheated PD patients and PD patients treated only with L-DOPA. We also measured platelet and plasma levels of L-DOPA, 3-O-methyldopa (the long-lasting metabolite of the drug), and dopamine. We found that isolated platelets of heated PD patientsform higher amounts of 2,3-dihydroxybenzoate, an index of hydroxyl radicalgeneration, than platelets of controls or untreated patients. In treated patients, platelet levels of 2,3-dihydroxybenzoate were positively correlated with platelet levels of L-DOPA, 3-O-methyldopa, and with the score of disease severity. Disease severity was correlated with platelet and plasma levels of L-DOPA, as well as with the daily intake of the drug. No significantdifferences in platelet levels of cytosolic and mitochondrial isoforms of the antioxidant enzyme superoxide dismutase were found between PD patients,either treated or unheated, and controls. Our findings lend further support to the hypothesis that L-DOPA might promote free radical formation in PD patients. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:54:31