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Titolo:
Opioids modulate cell division in the germinal zone of the late embryonic neocortex
Autore:
Reznikov, K; Hauser, KF; Nazarevskaja, G; Trunova, Y; Derjabin, V; Bakalkin, G;
Indirizzi:
Karolinska Inst, Dept Clin Neurosci, Sect Alcohol & Drug Addict Res, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Res, S-17176 Stockholm, Sweden Univ Kentucky, Coll Med, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 & Neurobiol, Lexington, KY 40536 USA Natl Cardiol Res Ctr, Moscow 121552, Russia Natl Cardiol Res Ctr Moscow Russia 121552 Res Ctr, Moscow 121552, Russia
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 11, anno: 1999,
pagine: 2711 - 2719
SICI:
0953-816X(199908)11:8<2711:OMCDIT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING RAT-BRAIN; GUINEA-PIG BRAIN; DNA-SYNTHESIS; FETAL BRAIN; CEREBRAL-CORTEX; GROWTH-HORMONE; NERVOUS-SYSTEM; MESSENGER-RNA; SPINAL-CORD; RECEPTOR;
Keywords:
cell proliferation; cerebral cortex; opioid agonists; mouse; naloxone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Bakalkin, G Karolinska Inst, Dept Clin Neurosci, Sect Alcohol & Drug Addict Res, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-171766 Stockholm, Sweden
Citazione:
K. Reznikov et al., "Opioids modulate cell division in the germinal zone of the late embryonic neocortex", EUR J NEURO, 11(8), 1999, pp. 2711-2719

Abstract

Opioid effects on cell division in the embryonic cerebral cortex were examined using two experimental approaches: (i) the presence of opioid receptors in the embryonic day 16 mouse neocortex was tested using immunohistochemical techniques; (ii) the values of the indices of [H-3]thymidine pulse labelled cells and mitotic indices were estimated in the ventricular zone of the embryonic day 16 mouse neocortex 2.5, 4.5 and 8.5 h after administration to pregnant females of selected opioid receptor agonists or the opioid antagonist naloxone. The immunohistochemical study demonstrated that distinct subpopulations of the ventricular zone cells express mu, delta or kappa opioid receptors. Acute exposure of mouse embryos to mu, delta and kappa opioidreceptor agonists or naloxone differentially affects the indices of [H-3] thymidine pulse labelled cells and mitotic indices indicating changes in the cell cycle composition. Treatment with the mu opioid receptor agonist D-Ala(2)-MePhe(4), Gly-ol(5)-enkephalin (DAGO), or the partially selective kappa opioid receptor agonist bremazocine, increased the [H-3]thymidine labelling and mitotic indices. In contrast, the delta receptor agonist (D-Ser(8))-leucine enkephalin-Thr (DSLET) produced a decrease in the labelled cell indices and mitotic indices. Naloxone provided a biphasic effect: a decrease in the values of labelled cell indices 2.5 h after naloxone administration,followed by an increase in the values of the indices at 4.5 and 8.5 h. These results suggest that the endogenous embryonic/maternal opioid systems are involved in the regulation of cell division in the ventricular zone of the late embryonic cortex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:28:41