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Titolo:
Identification and function of neonatal Fc receptor in mammary gland of lactating mice
Autore:
Cianga, P; Medesan, C; Richardson, JA; Ghetie, V; Ward, ES;
Indirizzi:
Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Med Ctr, Ctr Immunol, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Med Ctr, Dept Pathol, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Ctr Canc Immunobiol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Ctr Canc Immunobiol, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Ctr, Dept Microbiol, Dallas, TX 75235 USA
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 8, volume: 29, anno: 1999,
pagine: 2515 - 2523
SICI:
0014-2980(199908)29:8<2515:IAFONF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-RELATED RECEPTOR; AMINO-ACID-RESIDUES; RAT SMALL-INTESTINE; IMMUNOGLOBULIN-G; HUMAN PLACENTA; IGG TRANSPORTER; FETAL; MOUSE; TRANSMISSION; EXPRESSION;
Keywords:
neonatal Fc receptor; IgG; mammary gland; transcytosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Ward, ES Univ Texas, SW Med Ctr, Ctr Immunol, 5323 Harry Hines Blvd, Dallas, TX 75235 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75235 TX 75235 USA
Citazione:
P. Cianga et al., "Identification and function of neonatal Fc receptor in mammary gland of lactating mice", EUR J IMMUN, 29(8), 1999, pp. 2515-2523

Abstract

In addition to its proposed function in regulating serum IgG levels, the MHC class I-related neonatal Fc receptor (FcRn) is known to play a role in IgG transfer across rodent yolk sac and neonatal intestine. In contrast to humans, for which transplacental transfer of IgG appears to be the only mechanism of maternal IgG delivery, the transmission of IgG in mice occurs bothantenatally (yolk sac) and neonatally (transport from mother's milk acrossintestinal epithelial cells). In the current study, a possible role for FcRn in regulating IgG transfer into milk has been investigated. FcRn has been shown to be present in functional form in the mammary gland of lactating mice, and is localized to the epithelial cells of the acini. Analysis of the transfer of Pc fragments and IgG which have different affinities for FcRnindicate that, unexpectedly, these proteins are transferred in inverse correlation with their binding affinity for FcRn. Thus, in the lactating mammary gland FcRn appears to play a role in recycling IgG in a mode that may have relevance to FcRn trafficking during the maintenance of constant serum IgG levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:45:11