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Titolo:
Comparative selectivities of immobilized lipases from Pseudomonas cepacia and Candida antarctica (fraction B) for esterification reactions with glycerol and glycerol analogues in organic media
Autore:
Chang, QL; Lee, CH; Parkin, KL;
Indirizzi:
Univ Wisconsin, Dept Food Sci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Dept Food Sci, Madison, WI 53706 USA
Titolo Testata:
ENZYME AND MICROBIAL TECHNOLOGY
fascicolo: 3-5, volume: 25, anno: 1999,
pagine: 290 - 297
SICI:
0141-0229(199908)25:3-5<290:CSOILF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITIONAL SPECIFICITY INDEX; FATTY-ACID SELECTIVITY; CATALYZED ESTERIFICATION; MICROBIAL LIPASES; CARICA-PAPAYA; ENZYMATIC-REACTIONS; SECONDARY ALCOHOLS; WATER ACTIVITY; SOLVENTS; INTERESTERIFICATION;
Keywords:
lipase; Candida antarctica B lipase; Pseudomonas cepacia lipase; acyl group selectivity; glycerol analogue selectivity; acylglycerol restructuring; esterification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Parkin, KL Univ Wisconsin, Dept Food Sci, Babcock Hall,1605 Linden Dr, Madison, WI 53706 USA Univ Wisconsin Babcock Hall,1605 Linden Dr Madison WI USA 53706
Citazione:
Q.L. Chang et al., "Comparative selectivities of immobilized lipases from Pseudomonas cepacia and Candida antarctica (fraction B) for esterification reactions with glycerol and glycerol analogues in organic media", ENZYME MICR, 25(3-5), 1999, pp. 290-297

Abstract

Esterification reaction selectivity in homogeneous organic media was evaluated for Candida antarctica B and Pseudomonas cepacia lipases toward members of an homologous series of even carbon number, saturated n-fatty acids (FAs) of 4-16 carbons (C4-C16), glycerol, and glycerol analogues (n-propanol,isopropanol, 1,2-, and 1,3-propanediols). Dual FA optima were observed in almost all reaction mixtures, with C. antarctica and P. cepacia lipases generally favoring C10/C6 and C8/C16, respectively. Several explanations are offered to account for multiple FA optima. Reaction selectivity toward FAs was more influenced by steric than electronic features of FA substrates. Relative selectivity and discriminatory power among the series of FAs was modulated by the specific alcohol acceptor used. This may be founded on partialsharing of binding pockets by alcohol and FA co-substrates. Evidence was obtained that implicates the sn-2 alcohol functional group as being a determinant of FA selectivity and lipase discriminatory power. (C) 1999 Elsevier Science Inc. All rights reserved.

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Documento generato il 26/11/20 alle ore 19:32:25