Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C-elegans C42.C1.9
Autore:
Ikegawa, S; Isomura, M; Koshizuka, Y; Nakamura, Y;
Indirizzi:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Med,Minato Ku, Tokyo 108, Japan Univ Tokyo Tokyo Japan 108 e, Lab Genome Med,Minato Ku, Tokyo 108, Japan Univ Tokyo, Fac Med, Dept Orthopaed Surg, Bunkyo Ku, Tokyo 113, Japan UnivTokyo Tokyo Japan 113 t Orthopaed Surg, Bunkyo Ku, Tokyo 113, Japan
Titolo Testata:
CYTOGENETICS AND CELL GENETICS
fascicolo: 3-4, volume: 85, anno: 1999,
pagine: 227 - 231
SICI:
0301-0171(1999)85:3-4<227:CACOAN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEQUENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Ikegawa, S Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Med,Minato Ku, 4-6-1 Shirokanedai, Tokyo 108, Japan Univ Tokyo 4-6-1 Shirokanedai Tokyo Japan 108 Tokyo 108, Japan
Citazione:
S. Ikegawa et al., "Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C-elegans C42.C1.9", CYTOG C GEN, 85(3-4), 1999, pp. 227-231

Abstract

Large-scale sequencing of selected genomic regions, coupled with in silicogene trapping, is a robust approach to identifying previously unknown genes. In this way we have found a gene (C8orf2) that is highly homologous to C. elegans C42C1.9. C80rf2 was situated on 8p11.2 between STS markers NIB1979 (proximal) and AFMA295ZD5 (distal), oriented toward the centromere. C8orf2 consisted of 16 exons spanning more than 16.5 kb of genomic DNA, and was expressed ubiquitously in human tissues. The gene encoded 339-and 152-aminoacid polypeptides by alternative splicing; the larger variant contained a region extremely rich in charged amino acids, in particular lysine and glutamic acid. C80rf2 also bore sequence homology to the human KE04p gene. Its conservation among highly divergent species suggests that C8orf2 belongs toa novel gene family.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 04:29:04