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Titolo:
Fringe, Notch, and making developmental boundaries
Autore:
Irvine, KD;
Indirizzi:
Rutgers State Univ, Waksman Inst, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 Inst, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 chem, Piscataway, NJ 08854 USA
Titolo Testata:
CURRENT OPINION IN GENETICS & DEVELOPMENT
fascicolo: 4, volume: 9, anno: 1999,
pagine: 434 - 441
SICI:
0959-437X(199908)9:4<434:FNAMDB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL-DISTAL AXIS; DROSOPHILA EYE; VERTEBRATE SEGMENTATION; LUNATIC FRINGE; SOMITE SEGMENTATION; PATTERN-FORMATION; GENE-EXPRESSION; DELTA-HOMOLOG; SERRATE; DORSAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Irvine, KD Rutgers State Univ, Waksman Inst, 190 Frelinghuysen Rd, Piscataway, NJ 08854 USA Rutgers State Univ 190 Frelinghuysen Rd Piscataway NJ USA08854
Citazione:
K.D. Irvine, "Fringe, Notch, and making developmental boundaries", CUR OP GEN, 9(4), 1999, pp. 434-441

Abstract

Multiple mechanisms are involved in positioning and restricting specialized dorsal-ventral border cells in the Drosophila wing, including modulation of Notch signaling by Fringe, autonomous inhibition by Notch ligands, and inhibition of Notch target genes by Nubbin. Recent studies have revealed that Fringe also modulates a Notch-mediated signaling process between dorsal and ventral cells in the Drosophila eye, establishing an organizer of eye growth and patterning along the dorsal-ventral midline. Fringe-dependent modulation of Notch signaling also plays a key role in Drosophila leg segmentation and growth. Lunatic Fringe has been shown to be required for vertebratesomitogenesis, where it appears to act as a crucial link between a molecular clock and the regulation of Notch signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:49:14