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Titolo:
Diagnosis and subclassification of follicle center and mantle cell lymphomas on fine-needle aspirates - A cytologic and immunocytochemical approach based on the revised European-American lymphoma (REAL) classification
Autore:
Rassidakis, GZ; Tani, E; Svedmyr, E; Porwit, A; Skoog, L;
Indirizzi:
Karolinska Hosp, Dept Pathol & Cytol, Div Clin Cytol, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 ytol, S-17176 Stockholm, Sweden Univ Athens, Sch Med, Lab Histol & Embryol, GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 ol & Embryol, GR-11527 Athens, Greece Karolinska Hosp, Dept Oncol, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 ncol, S-17176 Stockholm, Sweden Karolinska Hosp, Dept Pathol & Cytol, Div Hematopathol, S-17176 Stockholm,Sweden Karolinska Hosp Stockholm Sweden S-17176 athol, S-17176 Stockholm,Sweden
Titolo Testata:
CANCER CYTOPATHOLOGY
fascicolo: 4, volume: 87, anno: 1999,
pagine: 216 - 223
SICI:
0008-543X(19990825)87:4<216:DASOFC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMAS; CYCLIN D1; LYMPHOCYTIC LYMPHOMA; MALIGNANT-LYMPHOMA; PROGNOSTIC FACTORS; EXPRESSION; PROPOSAL; ENTITY;
Keywords:
fine-needle aspiration; follicle center lymphoma; mantle cell lymphoma; immunocytochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tani, E Karolinska Hosp, Dept Pathol & Cytol, Div Clin Cytol, Box 100, S-17176 Stockholm, Sweden Karolinska Hosp Box 100 Stockholm Sweden S-17176 tockholm, Sweden
Citazione:
G.Z. Rassidakis et al., "Diagnosis and subclassification of follicle center and mantle cell lymphomas on fine-needle aspirates - A cytologic and immunocytochemical approach based on the revised European-American lymphoma (REAL) classification", CANC CYTOP, 87(4), 1999, pp. 216-223

Abstract

BACKGROUND. Cytologic distinction between follicle center lymphoma (FCL) and mantle cell lymphoma (MCL) is difficult with cytomorphology alone and requires immunophenotyping. The current study describes the distinction between follicle center and mantle cell lymphoma made with fine-needle aspiration (FNA) material. METHODS. One hundred ten cases primarily diagnosed and classified on FNA material as centroblastic-centrocytic (CBCC) and centrocytic (CC) non-Hodgkin lymphomas (NHLs) (Kiel classification) were included in the study. An additional retrospective immunocytochemical analysis was performed on frozen cytospin preparations using the monoclonal antibodies Bcl-2, CD10, CD5, CD23, CD43, and immunoglobulin M. RESULTS. The initial diagnostic workup classified 106 cases as CBCC-NHL and 4 as CC-NHL. The immunophenotype Bcl-2(+), CD10(+/-), CD5(-), CD23(-/+), CD43(-) was observed in 93 of 106 previously reported CBCC NHLs. In 11 of 106 cytospin preparations, neoplastic B cells expressed the CD5 pan T markerand, as a group, showed the pattern Bcl (+/-), CD10(-/+), CD5(+), CD23(-),CD43(+), which is considered typical of MCL. Based on the additional immunocytochemical data, all but 2 of the tumors were reclassified as FCL (n = 93) and MCL (n = 15). The mean proliferation fraction measured by MIB-1 (Ki-67) immunoreactivity was 16.3% and 17.5% in FCL and MCL, respectively. The revised cytopathologic diagnosis correlated significantly (P < 10(-9)) withthe histology of 65 patients who underwent surgical excision biopsy. CONCLUSIONS. Subclassification of follicle-derived low grade NHL can be established with high accuracy on FNA material if cytomorphology is corroborated by a complete immunophenotypic analysis, which can be performed on bothfresh and frozen stored cytospin material. The currently used criteria canbe applied to aspirated cells for a conclusive cytopathologic diagnosis ofMCL, which is of great clinical importance. (C) 1999 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:13:16