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Titolo:
Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victims
Autore:
Underwood, MD; Khaibulina, AA; Ellis, SP; Moran, A; Rice, PM; Mann, JJ; Arango, V;
Indirizzi:
New York State Psychiat Inst, Dept Neurosci, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Anat & Cell Biol, New York, NY USA Columbia Univ New York NY USA g, Dept Anat & Cell Biol, New York, NY USA Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA ittsburgh, Med Ctr, Pittsburgh, PA USA Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA Columbia Univ New York NY USA ys & Surg, Dept Psychiat, New York, NY USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 46, anno: 1999,
pagine: 473 - 483
SICI:
0006-3223(19990815)46:4<473:MOTDRN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUID MONOAMINE METABOLITES; DEFICIT HYPERACTIVITY DISORDER; TRITIATED IMIPRAMINE BINDING; ADRENERGIC-RECEPTOR BINDING; H-3 PAROXETINE BINDING; HUMAN BRAIN POSTMORTEM; MESSENGER-RNA LEVELS; 5-HT UPTAKE SITES; CEREBROSPINAL-FLUID; FRONTAL-CORTEX;
Keywords:
suicide; mental illness; serotonin; brainstem; quantitation; neuromorphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Underwood, MD New York State Psychiat Inst, Dept Neurosci, 1051 Riverside Dr Box 42, NewYork, NY 10032 USA New York State Psychiat Inst 1051 Riverside Dr Box 42 New York NY USA 10032
Citazione:
M.D. Underwood et al., "Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victims", BIOL PSYCHI, 46(4), 1999, pp. 473-483

Abstract

Background: The serotonin deficiency hypothesis of suicide has been important heuristically. Few studies have directly examined the brainstem dorsal raphe nucleus (DRN) serotonin neurons. We determined the number and morphometry of DRN serotonergic neurons in suicide victims (n = 7) compared to controls (n = 6). Methods: Brainstems were collected at autopsy, fixed and cryoprotected. Tissue was sectioned, stained for Nissl and processed with an antiserum that cross-reacts with tryptophan hydroxylase. All DRN neurons were identified, counted and analyzed every 1000 mu m. Neuron morphometry was characterized by soma area (mu m(2)), sphericity, perimeter, length and density (neurons per mm(3)). Results: Neuron number and density was higher in suicide victims (1,780 +/- 127 neurons/mm(3)) than controls (1,349 +/- 68). The DRN volume did not differ between groups (66 +/- 9 mm(3) for controls vs. 67 +/- 5 mm(3) for suicides). Mean neuronal area and sphericity did not differ between suicides and controls. The total number and the density of DRN neurons did not correlate with age. Conclusions: The finding of an increased number of neurons indicates that impaired serotonergic transmission found in association with serious suicide attempts is not due to fewer neurons. Biol Psychiatry 1999;46:473-483 (C)1999 Society of Biological Psychiatry.

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Documento generato il 19/01/20 alle ore 20:32:58