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Titolo:
Effect of local anesthetic ropivacaine on isolated rat liver mitochondria
Autore:
Floridi, A; Di Padova, M; Barbieri, R; Arcuri, E;
Indirizzi:
Univ Aquila, Dept Expt Med, I-67100 Laquila, Italy Univ Aquila Laquila Italy I-67100 Dept Expt Med, I-67100 Laquila, Italy Regina Elena Inst Canc Res, Lab Cell Metab & Pharmacokinet, I-00161 Rome, Italy Regina Elena Inst Canc Res Rome Italy I-00161 kinet, I-00161 Rome, Italy Regina Elena Inst Canc Res, Dept Pain Control & Intens Care, I-00161 Rome,Italy Regina Elena Inst Canc Res Rome Italy I-00161 s Care, I-00161 Rome,Italy
Titolo Testata:
BIOCHEMICAL PHARMACOLOGY
fascicolo: 6, volume: 58, anno: 1999,
pagine: 1009 - 1016
SICI:
0006-2952(19990915)58:6<1009:EOLARO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE-PHOSPHORYLATION; BUPIVACAINE; INHIBITION; MECHANISM; NUPERCAINE; TETRACAINE; DEPRESSION; TRANSPORT; MEMBRANES; TOXICITY;
Keywords:
local anesthetics; ropivacaine; mitochondria; uncoupler; electron transport chain; rat liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Floridi, A Univ Aquila, Dept Expt Med, Via Vetoio,Coppito 2, I-67100 Laquila, Italy Univ Aquila Via Vetoio,Coppito 2 Laquila Italy I-67100 , Italy
Citazione:
A. Floridi et al., "Effect of local anesthetic ropivacaine on isolated rat liver mitochondria", BIOCH PHARM, 58(6), 1999, pp. 1009-1016

Abstract

Ropivacaine is a new long-acting aminoamide local anesthetic with a reduced systemic and cardiac toxicity. Since the latter seems to be related, at least partially, to an interference with mitochondrial energy transduction, the effect of ropivacaine on the metabolism of rat liver mitochondria was studied. Ropivacaine alone exhibited little effect on mitochondrial metabolism, whereas effects were strongly enhanced by tetraphenylboron (TPB-) anion. At low drug concentrations, state 4 respiration was stimulated and mitochondrial membrane potential collapsed. At higher concentrations, state 4 anduncoupled respiration were inhibited by impairment of electron transfer from NAD(-) and flavine adenine dinucleotide-linked substrates to the respiratory chain. The fact that TPB- increased drug effects indicated that stimulation of respiration was due to dissipation of the electrochemical proton gradient caused by its electrophoretic uptake, although a classical uncoupling mechanism cannot be excluded. The mechanism for the lower toxicity of ropivacaine in vivo was ascribed to low liposolubility leading to reduced access to the mitochondrial membrane, resulting in a minimal perturbation of mitochondrial metabolism. BIOCHEM PHARMACOL 58;6:1009-1016, 1999. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:00:20