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Titolo:
Inhibition of calcium signaling in ultraviolet-irradiated fibroblasts: Role of tyrosine phosphorylation and protein kinase C
Autore:
Bagchi, S; Bhaumik, G; Raha, S;
Indirizzi:
Saha Inst Nucl Phys, Crystallog & Mol Biol Div, Calcutta 700064, W Bengal,India Saha Inst Nucl Phys Calcutta W Bengal India 700064 700064, W Bengal,India
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 261, anno: 1999,
pagine: 504 - 510
SICI:
0006-291X(19990802)261:2<504:IOCSIU>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
THROMBIN-RECEPTOR; ACTIVATION; UV; TRANSDUCTION; LIGHT; CELLS; SPECIFICITY; INVOLVEMENT; GENISTEIN; PLATELETS;
Keywords:
ultraviolet C; calcium; thrombin; tyrosine phosphorylation; PKC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Raha, S Saha Inst Nucl Phys, Crystallog & Mol Biol Div, 1-AF Bidhannagar, Calcutta700064, W Bengal, India Saha Inst Nucl Phys 1-AF Bidhannagar Calcutta W Bengal India 700064
Citazione:
S. Bagchi et al., "Inhibition of calcium signaling in ultraviolet-irradiated fibroblasts: Role of tyrosine phosphorylation and protein kinase C", BIOC BIOP R, 261(2), 1999, pp. 504-510

Abstract

Our aim was to study whether ultraviolet radiation produced any alterations in the subsequent signaling response of V79 fibroblasts to mitogenic stimulus. In ultraviolet C (UVC)-irradiated V79 fibroblasts, increase in cytosolic calcium in response to thrombin was nearly abolished in the presence of3 mM external Ca2+. UVC-treated V79 cells showed a greatly enhanced permeability to Ca2+ which was reversed by pretreatment with genistein, a tyrosine kinase inhibitor. Genistein also alleviated the inhibition of thrombin response caused by WC. In WC-treated cells, significant activation of proteinkinase C (PKC) occurred only on exposure to 3 mM external calcium and PKC inhibitors (H-7 or staurosporine) reversed UVC-induced adverse effects on the thrombin response. Therefore, it is likely that protein tyrosine phosphorylation by UVC may play a role in the subsequent inhibition of thrombin response in V79 cells through increased calcium influx and activation of PKC. (C) 1999 Academic Press.

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Documento generato il 21/09/20 alle ore 03:21:30