Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Rapid and efficient inactivation of IL-6 gingipains, lysine- and arginine-specific proteinases from Porphyromonas gingivalis
Autore:
Banbula, A; Bugno, M; Kuster, A; Heinrich, PC; Travis, J; Potempa, J;
Indirizzi:
Jagiellonian Univ, Inst Mol Biol, PL-31120 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31120 l Biol, PL-31120 Krakow, Poland Rhein Westfal TH Aachen, Inst Biochem, D-5100 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-5100 em, D-5100 Aachen, Germany Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 Biochem & Mol Biol, Athens, GA 30602 USA
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 261, anno: 1999,
pagine: 598 - 602
SICI:
0006-291X(19990811)261:3<598:RAEIOI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYSTEINE PROTEINASES; HUMAN INTERLEUKIN-6; PERIPHERAL-BLOOD; PERIODONTITIS; EXPRESSION; RECEPTOR; ALPHA; ACTIVATION; DEPENDENCE; CYTOKINES;
Keywords:
proteinase; KGP; RGP-A; RGP-B; cytokine; periodontitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Potempa, J Jagiellonian Univ, Inst Mol Biol, Al Mickiewicza 3, PL-31120 Krakow, Poland Jagiellonian Univ Al Mickiewicza 3 Krakow Poland PL-31120 land
Citazione:
A. Banbula et al., "Rapid and efficient inactivation of IL-6 gingipains, lysine- and arginine-specific proteinases from Porphyromonas gingivalis", BIOC BIOP R, 261(3), 1999, pp. 598-602

Abstract

Deregulation of the cytokine network is an important adaptation of pathogenic bacteria to modulate and evade a host immune response. Here we describethat IL-6 is rapidly and efficiently cleaved and inactivated by the arginine- and lysine-specific proteinases from Porphyromonas gingivalis, referredto as RGP-A, RGP-B, and KGP. One of the primary cleavage sites for RGPs has been mapped between R18 and Q19 within the N-terminal region of the IL-6 polypeptide chain; however, both KGP and RGPs cleave IL-6 within the C-terminal region of the polypeptide chain. After these initial proteolytic cleavages, IL-6 is further degraded by each of the enzymes tested. Although KGP is the most potent IL-6-degrading proteinase, the initial C-terminal cleavage of IL-6 mediated by all gingipains is already sufficient to inactivate this cytokine. Our data are consistent with the observation that in periodontitis the IL-6 concentration is lowest in the gingival tissue adjacent to bacterial plaque, whereas significantly elevated concentrations of this cytokine are detected around the infected area. Degradation of IL-6 by gingipains may, therefore, represent an additional mechanism which influences the balance between pro- and anti-inflammatory reactions at distal versus proximal sites from the periodontal plaque, (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 15:13:28