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Titolo:
Genetic background determines the extent of atherosclerosis in ApoE-deficient mice
Autore:
Dansky, HM; Charlton, SA; Sikes, JL; Heath, SC; Simantov, R; Levin, LF; Shu, P; Moore, KJ; Breslow, JL; Smith, JD;
Indirizzi:
Rockefeller Univ, Biochem Genet & Metab Lab, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 Metab Lab, New York, NY 10021 USA Rockefeller Univ, Lab Stat Genet, New York, NY 10021 USA Rockefeller UnivNew York NY USA 10021 Stat Genet, New York, NY 10021 USA Cornell Univ Med Coll, Div Hematol Oncol, New York, NY USA Cornell Univ Med Coll New York NY USA iv Hematol Oncol, New York, NY USA Cornell Univ Med Coll, Div Cardiol, Dept Med, New York, NY USA Cornell Univ Med Coll New York NY USA ardiol, Dept Med, New York, NY USA Millennium Pharmaceut Inc, Cambridge, MA USA Millennium Pharmaceut Inc Cambridge MA USA maceut Inc, Cambridge, MA USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 8, volume: 19, anno: 1999,
pagine: 1960 - 1968
SICI:
1079-5642(199908)19:8<1960:GBDTEO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; DIET-INDUCED ATHEROSCLEROSIS; COLONY-STIMULATING FACTOR; QUANTITATIVE TRAIT LOCUS; APOLIPOPROTEIN-E; ATHEROGENIC DIET; TRANSGENIC MICE; BLOOD-PRESSURE; INBRED STRAINS; MOUSE STRAINS;
Keywords:
hypercholesterolemia; lipoproteins; apolipoproteins; intercross; oxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, JD Rockefeller Univ, Biochem Genet & Metab Lab, 1230 York Ave,Box 179, New York, NY 10021 USA Rockefeller Univ 1230 York Ave,Box 179 New York NY USA 10021 USA
Citazione:
H.M. Dansky et al., "Genetic background determines the extent of atherosclerosis in ApoE-deficient mice", ART THROM V, 19(8), 1999, pp. 1960-1968

Abstract

Two strains of ApoE-deficient mice were found to have markedly different plasma lipoprotein profiles and susceptibility to atherosclerosis when fed either a low-fat chow or a high-fat Western-type diet. FVB/NJ ApoE-deficient(FVB EO) mice had higher total cholesterol, HDL cholesterol, ApoA1, and ApoA2 levels when compared with C57BL/6J ApoE-deficient (C57 EO) mice. At 16 weeks of age, mean aortic root atherosclerotic lesion area was 7- to 9-foldhigher in chow diet-fed C57 EO mice and 3.5-fold higher in Western diet-fed C57 EO mice compared with FVB EO mice fed similar diets. Lesion area in chow diet-fed first-generation mice from a strain intercross was intermediate in size compared with parental values. The distribution of the lesion area in 150 chow diet-fed second-generation progeny spanned the range of the lesion area in both parental strains. There were no correlations between total cholesterol, non-HDL cholesterol, HDL cholesterol, ApoA1, ApoA2, ApoJ, or anti-cardiolipin antibodies and lesion area in the second-generation progeny. Thus, a genomic approach may succeed in identifying the genes responsible for the variation in atherosclerosis susceptibility in these 2 strains of ApoE-deficient mice, which could not: be explained by measured plasma parameters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:06:42