Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NuMA: Evaluation of a new biomarker for the detection of low stage colorectal cancer
Autore:
Briggman, J; Genduso, R; Camara, C; Healy, B; Shapiro, K; Roos, R; Merrifield, S; Lifter, J; Wu, YJ; Elder, E; Talamonti, M;
Indirizzi:
Matritech Inc, Immunoassay & Cell Syst, Newton, MA 02160 USA Matritech Inc Newton MA USA 02160 assay & Cell Syst, Newton, MA 02160 USA Univ Pittsburgh, Pittsburgh Canc Inst, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 nc Inst, Pittsburgh, PA 15213 USA Northwestern Univ, Lurie Canc Ctr, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 ie Canc Ctr, Chicago, IL 60611 USA
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 4A, volume: 19, anno: 1999,
pagine: 2411 - 2414
SICI:
0250-7005(199907/08)19:4A<2411:NEOANB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOTIC APPARATUS PROTEIN; NUCLEAR MATRIX PROTEINS; CELL; GENE;
Keywords:
NuMA; nuclear matrix protein; colon rectal cancer; diagnostic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Briggman, J Matritech Inc, Immunoassay & Cell Syst, 330 Nevada St, Newton,MA 02160 USA Matritech Inc 330 Nevada St Newton MA USA 02160 , MA 02160 USA
Citazione:
J. Briggman et al., "NuMA: Evaluation of a new biomarker for the detection of low stage colorectal cancer", ANTICANC R, 19(4A), 1999, pp. 2411-2414

Abstract

An enzyme immunoassay for NuMA was evaluated in a retrospective clinical study for its potential utility in the detection of colorectal cancer. The concentrations of NuMA and CEA (Abbott IMx) were measured in sera from 86 patients (presurgical) with colorectal cancer, 72 subjects with benign gastrointestinal diseases, 80 subjects with risk factors for colorectal cancer, and 141 age-matched healthy subjects. Reference values for NuMA and CEA werecalculated by two methods: 95% cumulative distribution and ROC analyses versus healthy subjects. By the first method, NuMA and CEA both had approximately 20% sensitivity for colorectal cancel: By the second method (which generated lower reference values), NuMA was more sensitive than CEA for colorectal cancer. This improved sensitivity was most evident in Dukes B subjects. By either analysis method, NuMA was more sensitive than CEA for subjects at risk for developing colorectal cancer whereas CEA was more specific for benign gastrointestinal diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:00:27