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Titolo:
Japanese encephalitis vaccine (inactivated, BIKEN) in US soldiers: Immunogenicity and safety of vaccine administered in two dosing regimens
Autore:
Defraites, RF; Gambel, JM; Hoke, CH; Sanchez, JL; Withers, BG; Karabatsos, N; Shope, RE; Tirrell, S; Yoshida, I; Takagi, M; Meschievitz, CK; Tsai, TF;
Indirizzi:
Walter Reed Army Inst Res, Div Prevent Med, Washington, DC 20307 USA Walter Reed Army Inst Res Washington DC USA 20307 ashington, DC 20307 USA Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Washington, DC 20307 USA Walter Reed Army Inst Res Washington DC USA 20307 ashington, DC 20307 USA Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA Ctr Dis Control & Prevent Ft Collins CO USA 80522 t Collins, CO 80522 USA Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, Yale Arbovirus Res Unit,Connecticut Emerging Infe, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 t Emerging Infe, New Haven, CT 06520 USA Pasteur Merieux Connaught Inc, Swiftwater, PA 18370 USA Pasteur Merieux Connaught Inc Swiftwater PA USA 18370 water, PA 18370 USA Osaka Univ, Kanoji Inst, Res Inst Microbial Dis, Osaka, Japan Osaka Univ Osaka Japan anoji Inst, Res Inst Microbial Dis, Osaka, Japan
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 2, volume: 61, anno: 1999,
pagine: 288 - 293
SICI:
0002-9637(199908)61:2<288:JEV(BI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODY-RESPONSE; YELLOW-FEVER; NEUTRALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Defraites, RF Walter Reed Army Inst Res, Div Prevent Med, Washington, DC 20307 USA Walter Reed Army Inst Res Washington DC USA 20307 20307 USA
Citazione:
R.F. Defraites et al., "Japanese encephalitis vaccine (inactivated, BIKEN) in US soldiers: Immunogenicity and safety of vaccine administered in two dosing regimens", AM J TROP M, 61(2), 1999, pp. 288-293

Abstract

The safety and immunogenicity of Japanese encephalitis (JE) vaccine (Nakayama strain, monovalent / BIKEN) was studied in 538 U.S. soldiers in 1990. Three doses of vaccine from three consecutively manufactured lots were givenon days 0, 7, and either 14 or 30. Serum for antibody determination was drawn at months 0, 2, and 6. Japanese encephalitis plaque reduction neutralization tests were pel formed by three laboratories on each specimen. Five hundred twenty-eight (98%) participants completed the immunization series. All recipients without antibody before immunization developed neutralizing antibody against JE virus. There were no differences in geometric mean titer among the three test lots at months 2 and 6. Soldiers who received the third dose on day 30 had higher titers at both time points. Antibody to yellow fever had no significant effect on immune response to vaccine. Conclusions drawn from analysis of serologic data from the three labs were nearly identical. Symptoms were generally limited to mild local effects and were reduced in frequency with each subsequent does in the series (21% to 11%; P < 0.0001). Generalized symptoms were rare (e.g., fever = 5%) with no reported cases of anaphylaxis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 15:38:14