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Titolo:
A systematic review of Helicobacter pylori eradication therapy - the impact of antimicrobial resistance on eradication rates
Autore:
Houben, MHMG; Van de Beek, D; Hensen, EF; De Craen, AJM; Rauws, EAJ; Tytgat, GNJ;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
fascicolo: 8, volume: 13, anno: 1999,
pagine: 1047 - 1055
SICI:
0269-2813(199908)13:8<1047:ASROHP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIC-ULCER DISEASE; LANSOPRAZOLE-QUADRUPLE THERAPY; WEEK TRIPLE THERAPY; METRONIDAZOLE RESISTANCE; ANTIBIOTIC-RESISTANCE; ROUTINE TREATMENT; DUODENAL-ULCER; IN-VITRO; INFECTION; CLARITHROMYCIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Houben, MHMG Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
M.H.M.G. Houben et al., "A systematic review of Helicobacter pylori eradication therapy - the impact of antimicrobial resistance on eradication rates", ALIM PHARM, 13(8), 1999, pp. 1047-1055

Abstract

Background: We systematically reviewed all available data in the literature to determine the overall eradication rates of currently advised Helicobacter pylori eradication regimens and to resolve conflicting evidence on the impact of antimicrobial resistance on the eradication rates. Methods: A comprehensive search of all published trials on H. pylori eradication therapy was carried out via an electronic database search, hand-searching and checking reference lists of pharmaceutical companies and other reviews, Full papers and abstracts in the English language which study currently advised eradication regimes were included. Results: 770 study-arms were analysed. Mean eradication rates for bismuth based triple, proton pump inhibitor triple, quadruple and ranitidine bismuth citrate combination therapies vary from 65 to 92%, In case of nitroimidazole resistance, a drop in efficacy of up to 50% was found for bismuth-basedtriple and proton pump inhibitor-based triple therapies, For quadruple therapy, a significant difference in efficacy was found in the equal-effects analysis; however, this could not be confirmed in the random-effects analysis. In case of clarithromycin resistance, a mean drop in efficacy of 56% wasfound for one- and two-week clarithromycin containing proton pump inhibitor-triple therapies and of 58% for two-week ranitidine bismuth citrate combined with clarithromycin therapies. For ranitidine bismuth citrate combined with clarithromycin and nitroimidazole, no difference in efficacy was foundin case of nitroimidazole or clarithromycin resistance, but data are stillscarce. Conclusions: The cure rate with most regimens dropped significantly, in case of nitroimidazole-resistant strains, compared to nitroimidazole-susceptible strains. In case of clarithromycin resistance, the efficacy of most regimens is also decreased; however, data are still scarce. These data should allow physicians to make a better choice of an appropriate therapy for their patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 13:51:13