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Titolo:
Altered gene expression tn the foetal rat testis following the oestrogen exposure
Autore:
Majdic, G; Saunders, PTK;
Indirizzi:
MRC, Reprod Biol Unit, Edinburgh EH3 9EW, Midlothian, Scotland MRC Edinburgh Midlothian Scotland EH3 9EW h EH3 9EW, Midlothian, Scotland
Titolo Testata:
ACTA CHIMICA SLOVENICA
fascicolo: 1, volume: 45, anno: 1998,
pagine: 59 - 67
SICI:
1318-0207(1998)45:1<59:AGETTF>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY; SERTOLI; SEMEN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Majdic, G Fac Vet Med, Gerbiceva 60, Ljubljana 1000, Slovenia Fac Vet Med Gerbiceva 60 Ljubljana Slovenia 1000 1000, Slovenia
Citazione:
G. Majdic e P.T.K. Saunders, "Altered gene expression tn the foetal rat testis following the oestrogen exposure", ACTA CHIM S, 45(1), 1998, pp. 59-67

Abstract

Several reports in recent years have shown evidence for increasing incidence of male reproductive problems as cryptorchidism hypospadias and testicular cancer. In addition, several reports have published evidence far decrease in sperm counts in many western countries, which mig)lt be as high as 50%in the last 50 years. One hypothesis hare linked this problems to increased exposure to oestrogenic chemicals during foetal development. Aim of our studies was to establish whether environmental oestrogens could affect testicular development in rats. Time-mated pregnant rats were treated subcutaneously with either diethylstilbestrol (DES, potent synthetic oestrogen), octylphenol (OP, environmental oestrogen) or oil alone as control on days 11.5 and 15.5 p.c. Animals were sacrificed on day 17.5 p.c. Testes were dissected from their foetuses and either fixed in Bouin's solution. used for RNA extraction or used directly for measuring P450c17 enzyme activity. Lower activity and expression of steroidogenic enzyme P450c17 has been detected in the testes from foetuses whose mothers received either DES or OF. In addition, reduced expression of recently discovered transcription factor Steroidogenic factor-I (SF-1) has been detected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:39:46