Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment
Autore:
Ingelman-Sundberg, M; Oscarson, M; McLellan, RA;
Indirizzi:
Karolinska Inst, IMM, Div Mol Toxicol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 icol, S-17177 Stockholm, Sweden
Titolo Testata:
TRENDS IN PHARMACOLOGICAL SCIENCES
fascicolo: 8, volume: 20, anno: 1999,
pagine: 342 - 349
Fonte:
ISI
Lingua:
ENG
Soggetto:
S-MEPHENYTOIN; CHINESE SUBJECTS; CYP2D6 GENE; DEBRISOQUINE HYDROXYLATION; COUMARIN 7-HYDROXYLATION; OMEPRAZOLE METABOLISM; URINARY-EXCRETION; POOR METABOLIZERS; IN-VITRO; POPULATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Ingelman-Sundberg, M Karolinska Inst, IMM, Div Mol Toxicol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 lm, Sweden
Citazione:
M. Ingelman-Sundberg et al., "Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment", TRENDS PHAR, 20(8), 1999, pp. 342-349

Abstract

Approximately 40% of human P450-dependent drug metabolism is carried out by polymorphic enzymes, which can cause abolished, quantitatively or qualitatively altered or enhanced drug metabolism. The latter situation is due to stable duplication, multiduplication or amplification of active genes, mostlikely in response to dietary components that have resulted in a selectionof alleles with multiple non-inducible genes. Several examples exist wheresubjects carrying certain alleles suffer from a lack of drug efficacy due to ultrarapid metabolism or, alternatively, adverse effects from the drug treatment due to the presence of defective alleles. Knowledge in this field has grown rapidly and can now be applied to both drug development and clinical practice. This is facilitated by the recent development of high-throughput methods for mutation detection and oligonucleotide chips array technology for the identification of a multitude of mutations in the genes encodingdrug-metabolizing enzymes. The outcome will allow for safer and more efficient drug therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:02:01