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Titolo:
Ions in the fire: recent ion-channel research and approaches to pain therapy
Autore:
Eglen, RM; Hunter, JC; Dray, A;
Indirizzi:
Roche Biosci, Biol Res Ctr, Palo Alto, CA 94024 USA Roche Biosci Palo Alto CA USA 94024 Biol Res Ctr, Palo Alto, CA 94024 USA Astra Res Ctr Montreal, Montreal, PQ H4S 129, Canada Astra Res Ctr Montreal Montreal PQ Canada H4S 129 eal, PQ H4S 129, Canada
Titolo Testata:
TRENDS IN PHARMACOLOGICAL SCIENCES
fascicolo: 8, volume: 20, anno: 1999,
pagine: 337 - 342
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY NEURONS; SODIUM CURRENT; ATP RECEPTOR; RAT; GABAPENTIN; SUBUNITS; CLONING; GANGLIA; FAMILY; P2X(7);
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Eglen, RM Roche Biosci, Biol Res Ctr, Palo Alto, CA 94024 USA Roche Biosci Palo Alto CA USA 94024 tr, Palo Alto, CA 94024 USA
Citazione:
R.M. Eglen et al., "Ions in the fire: recent ion-channel research and approaches to pain therapy", TRENDS PHAR, 20(8), 1999, pp. 337-342

Abstract

Ion channels form a diverse and sophisticated collection of membrane-boundproteins. They are influenced by many endogenous compounds and physiological stimuli and modulate neuronal activity. It is thus unsurprising that they provide attractive targets for the design of novel therapeutics. In this article, recent ion channel research and its relevance to modulation of sensory transmission is assessed. In pain research, specific blockade or activation of ion channels has long been considered a desired route for identification of analgesics. Historically, this has proven difficult to attain dueto the incidence of side-effects associated with most ion-channel modulators. The recent discovery of several novel classes of ion channels, each of which has a specific distribution and role in sensory processing and nociception, has provided a plethora of targets for pharmaceutical intervention with the promise of an improved therapeutic index.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:10:55