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Titolo:
TRANSIENT AND PERSISTENT CONSEQUENCES OF ACUTE STRESS ON LONG-TERM POTENTIATION (LTP), SYNAPTIC EFFICACY THETA-RHYTHMS AND BURSTS IN AREA CA1 OF THE HIPPOCAMPUS
Autore:
SHORS TJ; GALLEGOS RA; BREINDL A;
Indirizzi:
PRINCETON UNIV,DEPT PSYCHOL PRINCETON NJ 08544 PRINCETON UNIV,PROGRAM NEUROSCI PRINCETON NJ 08544
Titolo Testata:
Synapse
fascicolo: 3, volume: 26, anno: 1997,
pagine: 209 - 217
SICI:
0887-4476(1997)26:3<209:TAPCOA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ACTIVATION; RAT HIPPOCAMPUS; DENTATE GYRUS; SLOW ACTIVITY; AMPA BINDING; INDUCTION; STIMULATION; BEHAVIOR; EXPRESSION; REGION;
Keywords:
HIPPOCAMPUS; STRATUM RADIATUM; ELECTROENCEPHALOGRAPHY (EEG); N-METHYL-D-ASPARTATE (NMDA); FEAR; LEARNING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Shors et al., "TRANSIENT AND PERSISTENT CONSEQUENCES OF ACUTE STRESS ON LONG-TERM POTENTIATION (LTP), SYNAPTIC EFFICACY THETA-RHYTHMS AND BURSTS IN AREA CA1 OF THE HIPPOCAMPUS", Synapse, 26(3), 1997, pp. 209-217

Abstract

Previous studies reported that exposure to an acute stressor of restraint and intermittent tailshock impairs long-term potentiation (LTP) in area CA1 of the rat hippocampus. In the first experiment, the longevity of the stress-induced impairment of LTP was determined. LTP of theexcitatory postsynaptic potential (EPSP) was impaired 2 but not 4 days after stressor cessation. Exposure to the stressor also persistentlyenhanced the synaptic response to the tetanic stimulation patterned after theta rhythm activity (10, 100 Hz bursts delivered at 5 Hz). In asecond experiment, we tested the hypothesis that exposure to the stressor enhanced synaptic efficacy itself. EPSPs were recorded from freely moving rats before, during and after stressor exposure. The synapticresponse was not enhanced during stressor exposure. Instead, cessation of the stressor (and perhaps movement associated with release from restraint) induced a transient (<2 min) decrease in synaptic efficacy. To determine whether exposure to the stressor enhances endogenous theta rhythms in area CA1, electroencephalographic (EEG) recordings were obtained from freely moving rats before, during and after exposure to the stressor. The power of theta (4-8 Hz) and low frequency (0.1-3.9 Hz) activity was enhanced in response to the tailshock aspect of the stressor. Together, the results indicate that exposure to an acute stressful event increases theta activity and its cessation transiently decreases synaptic efficacy. These transient effects are succeeded by a persistently sensitized response to theta burst stimulation and impaired LTP. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:02:48