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Titolo:
Is QT interval a marker of subclinical atherosclerosis in nondiabetic subjects? The insulin resistance atherosclerosis study (IRAS)
Autore:
Festa, A; DAgostino, R; Rautaharju, P; OLeary, DH; Rewers, M; Mykkanen, L; Haffner, SM;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Med, Div Clin Epidemiol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 Epidemiol, San Antonio, TX 78284 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27103 USA Wake Forest Univ Winston Salem NC USA 27103 , Winston Salem, NC 27103 USA EPICARE Ctr, Winston Salem, NC USA EPICARE Ctr Winston Salem NC USAEPICARE Ctr, Winston Salem, NC USA Tufts Univ, Sch Med, Dept Radiol, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Sch Med, Dept Radiol, Boston, MA 02111 USA Univ Colorado, Sch Med, Dept Prevent Med & Biometr, Denver, CO USA Univ Colorado Denver CO USA , Dept Prevent Med & Biometr, Denver, CO USA
Titolo Testata:
STROKE
fascicolo: 8, volume: 30, anno: 1999,
pagine: 1566 - 1571
SICI:
0039-2499(199908)30:8<1566:IQIAMO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTIMA-MEDIA THICKNESS; INDEPENDENT RISK FACTOR; B-MODE ULTRASOUND; CAROTID-ARTERY; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; AUTONOMIC NEUROPATHY; WALL THICKNESS; HEART-DISEASE; SUDDEN-DEATH;
Keywords:
atherosclerosis; carotid arteries; electrocardiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Festa, A Univ Texas, Hlth Sci Ctr, Dept Med, Div Clin Epidemiol, 7703 Floyd Curl Dr, San Antonio, TX 78284 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78284 78284 USA
Citazione:
A. Festa et al., "Is QT interval a marker of subclinical atherosclerosis in nondiabetic subjects? The insulin resistance atherosclerosis study (IRAS)", STROKE, 30(8), 1999, pp. 1566-1571

Abstract

Background and Purpose-We studied the relationship of heart rate-correctedQT interval with subclinical atherosclerosis, as determined by ultrasonographic measurement of carotid intima-media thickness (IMT) in nondiabetic subjects in the Insulin Resistance Atherosclerosis Study (IRAS). Prolonged heart rate-corrected QT interval is an unfavorable prognostic factor of cardiovascular morbidity and mortality, and QT interval prolongation may be the result of atherosclerosis. Methods-B-mode ultrasound imaging of the carotid artery IMT was performed in a large, triethnic, nondiabetic population free of clinical coronary artery disease (n=912). QT interval was measured on resting electrocardiogramswith use of a computer program and corrected for heart rate with standard equations. Results-IMT of the common carotid artery correlated significantly with heart rate-corrected QT interval duration (r=0.15 for QT(60) and r=0.14 for QTc), whereas no relationship between IMT of the internal carotid artery and QT interval was found (r=-0.01). The association was somewhat stronger in women than in men. In a multiple regression analysis adjusting for demographic variables, the association of common carotid artery IMT to heart rate-corrected QT interval remained highly significant, but adjustment for cardiovascular risk factors weakened the relationship. Conclusions-We found a significant relation of heart rate-corrected QT interval to carotid atherosclerosis in nondiabetic subjects that was stronger in women and partly mediated by cardiovascular risk factors, including hypertension. QT interval may therefore serve as a marker for clinically undetected ("subclinical") atherosclerotic disease.

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Documento generato il 30/11/20 alle ore 05:07:17