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Titolo:
Use of bioconjugates for the oral delivery of peptides, proteins and immunogens
Autore:
Russell-Jones, G;
Indirizzi:
Biotech Australia Pty Ltd, Roseville, NSW 2069, Australia Biotech Australia Pty Ltd Roseville NSW Australia 2069 SW 2069, Australia
Titolo Testata:
STP PHARMA SCIENCES
fascicolo: 1, volume: 9, anno: 1999,
pagine: 47 - 59
SICI:
1157-1489(199901/02)9:1<47:UOBFTO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXIN-B-SUBUNIT; LABILE ENTERO-TOXIN; RECEPTOR-MEDIATED ENDOCYTOSIS; PHASEOLUS-VULGARIS LECTINS; COLONY-STIMULATING FACTOR; RAT INTESTINAL-MUCOSA; ESCHERICHIA-COLI; CHOLERA-TOXIN; HEAT-LABILE; EPITHELIAL-CELLS;
Keywords:
cotransporters; peptides; proteins; nanoparticles;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Russell-Jones, G Biotech Australia Pty Ltd, POB 20, Roseville, NSW 2069, Australia Biotech Australia Pty Ltd POB 20 Roseville NSW Australia 2069
Citazione:
G. Russell-Jones, "Use of bioconjugates for the oral delivery of peptides, proteins and immunogens", STP PHARM S, 9(1), 1999, pp. 47-59

Abstract

The oval delivery of peptide and protein pharmaceuticals has been a problem that has vexed the pharmaceutical industry for many years. Uptake of these molecules is hindered by the highly proteolytic environment of the small intestine as well as the almost impenetrable barrier that the intestinal epithelial layer presents to peptides and proteins. Recent developments have suggested that it may be easier to overcome this barrier than first thought. This review concentrates on the many molecules that have now been identified that readily gain access through the intestinal epithelial cells and that can be used to cotransport other molecules covalently linked to these carriers. In a further extension to these findings it has also been found that it is possible to link these carriers to nanoparticles and also get thesestructures taken up by the endothelial cells and transported through the cells and into the circulation. These findings go a long way to solving the problems of oral delivery of peptide and protein pharmaceuticals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:28:21