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Titolo:
Pulmonary function in chronic heart failure - Changes after heart transplantation
Autore:
Ulrik, CS; Carlsen, J; Arendrup, H; Aldershvile, J;
Indirizzi:
Univ Copenhagen, Rigshosp, Dept Clin Physiol & Nucl Med KF, DK-1168 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-1168 , DK-1168 Copenhagen, Denmark Univ Copenhagen, Rigshosp, Dept Med B, Div Cardiol, DK-1168 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-1168 , DK-1168 Copenhagen, Denmark Univ Copenhagen, Rigshosp, Dept Cardiothorac Surg RT, DK-1168 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-1168 , DK-1168 Copenhagen, Denmark
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 3, volume: 33, anno: 1999,
pagine: 131 - 136
SICI:
1401-7431(1999)33:3<131:PFICHF>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC DILATED CARDIOMYOPATHY; CARDIAC TRANSPLANTATION; DIFFUSING-CAPACITY; RECIPIENTS; ABNORMALITIES; CYCLOSPORINE;
Keywords:
chronic heart failure; diffusion capacity; heart transplantation; pulmonary function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ulrik, CS Virum Overdrevsvej 13, DK-2830 Virum, Denmark Virum Overdrevsvej 13 Virum Denmark DK-2830 830 Virum, Denmark
Citazione:
C.S. Ulrik et al., "Pulmonary function in chronic heart failure - Changes after heart transplantation", SC CARDIOVA, 33(3), 1999, pp. 131-136

Abstract

To investigate the impact of chronic heart failure on pulmonary function in heart transplant recipients, pulmonary function was evaluated in 41 consecutive patients (mean age 43 years, range 15-57 years) before and 6 months after successful heart transplantation. The pulmonary function tests included measurements of forced vital capacity [FVC], forced expiratory volume in1.s [FEV1], FEV1/FVC ratio, total lung capacity [TLC], and diffusion capacity for carbon monoxide [T-LCO] and KCO [T-LCO per 1 alveolar volume]. Compared to pretransplant values, spirometry after transplantation revealed modest improvements in FVC (from 77 +/- 16 to 88 +/- 21% of predicted [%pred]; p < 0.001) and FEV1 (from 75 +/- 16 to 85 +/- 22%pred; p < 0.001), whereas the FEV1/FVC ratio was unchanged (81% +/- 11 and 80% +/- 10; p = NS). A slight but statistically significant increase in TLC (from 78 +/- 15 to 86 +/- 18%pred, p < 0.001) was also observed. Prior to transplantation the mean T-LCO was 76 +/- 17%pred; 7 of the patients had a T-LCO below 60%pred (mean 51% pred). In 33 of the 41 patients a reduction in T-LCO was observedafter transplantation; for all 41 patients the mean fall in T-LCO was 14% of the predicted value (SD 12%pred) (p < 0.0001). Likewise, a significant reduction in KCO was noted (p < 0.0001). Multiple regression analysis revealed that high pretransplant T-LCO %pred (p = 0.02) and FVC %pred (p = 0.04) were associated with a less favorable outcome concerning posttransplant T-LCO %pred. Although normalization of FEV1, FVC and TLC can be anticipated after correction of severe chronic left ventricular failure by heart transplantation, the pronounced concomitant decline in diffusion capacity observed in this study may be explained by underlying pulmonary disease caused by factors other than long-standing heart failure. Our findings support the notion that pulmonary function abnormalities attributable to chronic heart failure should not preclude consideration for heart transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 14:01:31