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Titolo:
Determination of absolute concentrations of cardiac high-energy phosphatesusing P-31-MR-spectroscopy and SLOOP in healthy and diseased myocardium.
Autore:
Beer, M; Landschutz, W; Meininger, M; Seyfarth, T; Viehrig, M; Sandstede, J; Pabst, T; Kenn, W; Horn, M; Harre, K; von Kienlin, M; Neubauer, S; Hahn, D;
Indirizzi:
Univ Wurzburg, Inst Rontgendiagnost, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 agnost, D-97070 Wurzburg, Germany Univ Wurzburg, Inst Phys, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 t Phys, D-97070 Wurzburg, Germany Univ Wurzburg, Med Klin, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 d Klin, D-97070 Wurzburg, Germany
Titolo Testata:
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
fascicolo: 1, volume: 171, anno: 1999,
pagine: 65 - 68
SICI:
0936-6652(199907)171:1<65:DOACOC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
GER
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; CORONARY-ARTERY DISEASE; LOCALIZATION; HEART; NMR; MRS;
Keywords:
nuclear magnetic resonance; spectroscopy; high energy phosphate; quantitative measurements;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Beer, M Univ Wurzburg, Inst Rontgendiagnost, Josef-Schneider-Str 2, D-97070 Wurzburg, Germany Univ Wurzburg Josef-Schneider-Str 2 Wurzburg Germany D-97070 many
Citazione:
M. Beer et al., "Determination of absolute concentrations of cardiac high-energy phosphatesusing P-31-MR-spectroscopy and SLOOP in healthy and diseased myocardium.", ROFO-F RONT, 171(1), 1999, pp. 65-68

Abstract

Purpose: A quantitative P-31-MR-spectroscopic technique was used to assessthe energy metabolism in healthy and diseased myocardium. Methods: P-31-spectra were acquired on a 1.5 T scanner using a 3D-chemical shift imaging technique. Based on the anatomical information provided by H-1-images, SLOOP (Spatial Localization with Optimal Pointspread Function) allows to obtain spectra from defined compartments. With SLOOP a free voxel shape with adaption to anatomic structures, e.g. the myocardium, is possible. Absolute values for phosphocreatine (PCr) and adenosine triphosphate (ATP) were determined using an external standard. Results: P-31-spectra showed only minimal contamination by surrounding tissue. The standard deviation for the determinedvalues of healthy volunteers was low. Compared to healthy volunteers, reduced PCr and ATP concentrations were seen for dilative cardiomyopathies and coronary artery disease and unchanged concentrations were observed for hypertensive heart disease. Conclusion: P-31-MR-spectroscopy with SLOOP allows a non-invasive, quantitative analysis of cardiac energy metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:58:23