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Titolo:
Interactive effects of subanesthetic ketamine and haloperidol in healthy humans
Autore:
Krystal, JH; DSouza, DC; Karper, LP; Bennett, A; Abi-Dargham, A; Abi-Saab, D; Cassello, K; Bowers, MB; Vegso, S; Heninger, GR; Charney, DS;
Indirizzi:
Vet Adm Med Ctr, W Haven, CT 06516 USA Vet Adm Med Ctr W Haven CT USA 06516 t Adm Med Ctr, W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA Connecticut Mental Hlth Ctr, Abraham Ribicoff Res Facil, New Haven, CT 06519 USA Connecticut Mental Hlth Ctr New Haven CT USA 06519 ew Haven, CT 06519 USA Cornell Univ, Med Ctr, Dept Neurol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 r, Dept Neurol, New York, NY 10021 USA New York State Psychiat Inst, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 145, anno: 1999,
pagine: 193 - 204
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTORS; PHENCYCLIDINE-INDUCED BEHAVIORS; NMDA RECEPTOR; PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; INDUCED PSYCHOSIS; BRAIN-REGIONS; RATING-SCALE; DOPAMINE; SCHIZOPHRENIA;
Keywords:
ketamine; N-methyl-D-asparate; glutamate; psychosis; dissociation; addiction; dopamine; neuroleptic; memory; attention; frontal cortex; extrapyramidal symptom; Wisconsin Card Sorting Test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Krystal, JH Vet Adm Med Ctr, W Haven, CT 06516 USA Vet Adm Med Ctr W Haven CT USA 06516 r, W Haven, CT 06516 USA
Citazione:
J.H. Krystal et al., "Interactive effects of subanesthetic ketamine and haloperidol in healthy humans", PSYCHOPHAR, 145(2), 1999, pp. 193-204

Abstract

Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist with prominent psychoactive effects in humans. This study evaluated whether the oral administration of haloperidol 5 mg would block the effects of an intravenousketamine infusion (bolus of 0.26 mg/kg followed by 0.65 mg/kg per hour). Twenty healthy subjects completed 4 test days involving the oral administration of haloperidol or matched placebo 2 h prior to the intravenous infusionof ketamine or saline. Ketamine produced cognitive, behavioral,:neuroendocrine, and physiologic effects in the healthy subjects that were similar to previous reports. Haloperidol pretreatment reduced impairments in executivecognitive functions produced by ketamine as measured by proverb interpretations and the Wisconsin Card Sorting Test. However, it failed to block the capacity of ketamine to produce psychosis, perceptual changes, negative symptoms, or euphoria in healthy subjects. These data outline an important, but functionally delineaeted modulation of ketamine effects by dopamine(2) receptors and other sites of haloperidol action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 20:53:14