Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of prepulses and d-amphetamine on performance and event-related potential measures an an auditory discrimination task
Autore:
Kroner, S; Schall, U; Ward, PB; Sticht, G; Banger, MW; Haffner, HT; Catts, SV;
Indirizzi:
Univ Newcastle, Fac Med & Hlth Sci, Discipline Psychiat, Callaghan, NSW 2308, Australia Univ Newcastle Callaghan NSW Australia 2308 allaghan, NSW 2308, Australia Ruhr Univ Bochum, Dept Biopsychol, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 iopsychol, D-4630 Bochum, Germany Univ Essen Gesamthsch, Clin Gen Psychiat, D-45147 Essen, Germany Univ Essen Gesamthsch Essen Germany D-45147 hiat, D-45147 Essen, Germany Univ New S Wales, Sch Psychiat, Schizophrenia Res Unit, Sydney, NSW, Australia Univ New S Wales Sydney NSW Australia a Res Unit, Sydney, NSW, Australia Univ Cologne, Inst Forens Med, Cologne, Germany Univ Cologne Cologne Germany Cologne, Inst Forens Med, Cologne, Germany Univ Essen Gesamthsch, Inst Forens Med, D-45147 Essen, Germany Univ Essen Gesamthsch Essen Germany D-45147 Med, D-45147 Essen, Germany
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 145, anno: 1999,
pagine: 123 - 132
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; STARTLE REFLEX; INTRACEREBRAL POTENTIALS; SCHIZOPHRENIC-PATIENTS; PREFRONTAL LESIONS; HEALTHY-SUBJECTS; 5-HT MODULATION; VISUAL-STIMULI; P300 COMPONENT; TEMPORAL-LOBE;
Keywords:
prepulse inhibition; sensorimotor gating; auditory discrimination task; Go/NoGo procedure; selective attention; d-amphetamine; dopamine; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Schall, U Univ Newcastle, Fac Med & Hlth Sci, Discipline Psychiat, Callaghan, NSW 2308, Australia Univ Newcastle Callaghan NSW Australia 2308 NSW 2308, Australia
Citazione:
S. Kroner et al., "Effects of prepulses and d-amphetamine on performance and event-related potential measures an an auditory discrimination task", PSYCHOPHAR, 145(2), 1999, pp. 123-132

Abstract

Rationale: Prepulse inhibition (PPI) of the startle reflex is a measure ofsensorimotor gating, that is the processing of the startle stimulus (S2) is inhibited by the interfering processing of a closely preceding prepulse (S1). It has been demonstrated that PPI is disrupted in a variety of mental disorders and that several neurotransmitter systems, including dopamine, participate in the modulation of sensorimotor gating. Previous studies have also shown that a task-relevant S1 enhances PPI in healthy subjects but not in schizophrenic patients. These findings indicate an influence of attentional processes on sensorimotor gating and an impairment of this modulation in schizophrenia. Objective: Assuming a dopamine-mediated suppression of S1 processing as a mechanism of resource management and selective attention, which might be impaired in certain mental disorders, the present study investigated the effects of the indirect dopaminergic agonist d-amphetamine on prepulse-altered S2 discrimination and event related potentials (ERPs). Methods: Twelve healthy volunteers were tested in a double-blind, placebo-controlled experimental design. Here, S2 is the target in a difficult Go/NoGo auditory discrimination task. Results: Confirming our previous results, S2 processing is "accentuated" by a weak acoustic prepulse in healthy subjects, thus leading to a lower rate of errors of omission but also to more false alarms (i.e. a liberal response bias). This performance change correlated with a prepulse-induced increase in the amplitude of the P3 ERP towards non-targets ("prepulse-induced non-target positivity"; PINTP). In addition, the results of the present study show that under prepulse conditions amphetamine disrupts "S2 accentuation" associated with a dose-related reduction of the P2 component of the S1 response and a plasma level related reduction of PINTP. Conclusions: These data suggest an involuntary attentional shift towards S1 processing with increasing dopamine-release similar to that observedin patients with schizophrenia or OCD. It is concluded that sensory gatingalters selective attention via dopaminergic modulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:42:06