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Titolo:
The pulmonary cachexia syndrome: aspects of energy balance
Autore:
Congleton, J;
Indirizzi:
Hammersmith Hosp, Div Resp Med, London, England Hammersmith Hosp London England ith Hosp, Div Resp Med, London, England
Titolo Testata:
PROCEEDINGS OF THE NUTRITION SOCIETY
fascicolo: 2, volume: 58, anno: 1999,
pagine: 321 - 328
SICI:
0029-6651(199905)58:2<321:TPCSAO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIET-INDUCED THERMOGENESIS; OBSTRUCTIVE LUNG-DISEASE; AIR-FLOW LIMITATION; MALNOURISHED PATIENTS; NUTRITIONAL-STATUS; EXERCISE PERFORMANCE; BODY-WEIGHT; MUSCLE; EMPHYSEMA; EXPENDITURE;
Keywords:
pulmonary cachexia syndrome; chronic obstructive pulmonary disease; energy balance; body-weight loss; malnutrition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Congleton, J Worthing Gen Hosp, Lyndhurst Rd, Worthing BN11 2HR, England Worthing Gen Hosp Lyndhurst Rd Worthing England BN11 2HR and
Citazione:
J. Congleton, "The pulmonary cachexia syndrome: aspects of energy balance", P NUTR SOC, 58(2), 1999, pp. 321-328

Abstract

The present paper reviews current knowledge of the pulmonary cachexia syndrome with reference to chronic obstructive pulmonary disease (COPD). Aspects of incidence, aetiology and management are discussed. Malnutrition occursin approximately one-quarter to one-third of patients with moderate to severe COPD. Both fat mass and fat-free mass become depleted. Loss of fat-freemass is the more important and appears to be due to a depression of protein synthesis. Weight loss is an independent prognostic indicator of mortality, and is associated with increased morbidity and decreased health-related quality of life. The aetiology of malnutrition in CORD is not well understood. Reduced food intake does not seem to be the primary cause. Resting energy expenditure (REE) is elevated in a proportion of patients and probably contributes to negative energy balance. Measurement of actual REE is helpfulwhen considering the adequacy of nutritional supplementation. The underlying reason for a hypermetabolic state is not known. Although weight-losing CORD patients are not catabolic, nutritional supplementation alone does not appear to reverse the loss of fat-free mass. Strategies involving nutritional supplementation in combination with a second intervention are being explored, and there are some encouraging results using anabolic hormones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 12:52:07