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Titolo:
Morphine tolerance and dependence in mice with history of repeated exposures to NMDA receptor channel blockers
Autore:
Dravolina, OA; Belozertseva, IV; Sukhotina, IA; Bespalov, AY;
Indirizzi:
Pavlov Med Univ, Inst Pharmacol, Dept Psychopharmacol, Lab Behav Pharmacol, St Petersburg 197089, Russia Pavlov Med Univ St Petersburg Russia 197089 St Petersburg 197089, Russia
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 63, anno: 1999,
pagine: 613 - 619
SICI:
0091-3057(199908)63:4<613:MTADIM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
UP-REGULATION; ASPARTATE RECEPTORS; MK-801; ANTAGONISTS; RATS; BINDING; SENSITIZATION; PHENCYCLIDINE; SENSITIVITY; MEMANTINE;
Keywords:
dizocilpine; memantine; MRZ 2/579; morphine; tolerance; dependence; analgesia; social interaction test; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Bespalov, AY Pavlov Med Univ, Inst Pharmacol, Dept Psychopharmacol, Lab Behav Pharmacol, 6-8 Lev Tolstoy St, St Petersburg 197089, Russia Pavlov Med Univ 6-8 Lev Tolstoy St St Petersburg Russia 197089
Citazione:
O.A. Dravolina et al., "Morphine tolerance and dependence in mice with history of repeated exposures to NMDA receptor channel blockers", PHARM BIO B, 63(4), 1999, pp. 613-619

Abstract

Mice were subjected to two successive treatment protocols: first with NMDAreceptor channel blockers (14 days, once a day) and second with morphine (5 mg/kg, 8 days, once a day). Treatment with the higher doses of dizocilpine (1 mg/kg), memantine (30 mg/kg), and MRZ 2/576 (30 mg/kg) upon discontinuation revealed only minor behavioral abnormalities attributable to the state of withdrawal. Following repeated administration of low-dose morphine, tolerance to morphine analgesia developed in mice preexposed to dizocilpine (1 mg/kg but not 0.3 mg/kg) but not memantine (10 and 30 mg/kg), MRZ 2/579 (10 and 30 mg/kg), or saline. There were no signs of morphine dependence in any treatment group. Overall, the present study found only minor effects ofthe subchronic administration of high doses of NMDA receptor channel blockers, suggesting that clinical use of NMDA receptor channel blockers such asmemantine will not be accompanied by increased propensity to induction of morphine tolerance and dependence. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 06:19:15